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MetabolomicsImidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model
Ferroptosis is a form of regulated cell death that can be induced by inhibition of the cystine-glutamate antiporter, system xc-. Among the existing system xc- inhibitors, imidazole ketone erastin (IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially s...
2019-04-17 | MTBLS774 | MetaboLights
ProteomicsErastin induced protein expression change in H1975 cells
H1975 cells were treated with DMSO and erastin, respectively. Protein was extracted and separated using SDS-PAGE electrophoresis. MS analysis was performed and protein was identified and quantified using Proteome Discoverer™ 1.3 software using the SEQUEST® search engine.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020205 | Pride
Erastin Ferroptosis Lung cancer 
ProteomicsErastin and ferrostatin induced protein expression change in HepG2 cells
Project description: HepG2 cells were treated with DMSO, erastin and ferrostatin, respectively. Protein was extracted and separated using SDS-PAGE electrophoresis. MS analysis was performed and protein was identified and quantified using Proteome Discoverer™ 1.3 software using the SEQUEST® search en...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD010761 | Pride
Erastin Ferroptosis Liver cancer 
ProteomicsPhosphoproteomic analysis of Hemin- and Erastin-induced neuronal death
Analysis of the differences in phosphorylation in two ferroptosis subtypes (Hemin vs classical erastin-induced ferroptosis) in neurons, and sensitivity of these changes in phosphorylation levels to treatment with ferroptosis suppressor and MEK inhibitor U0126.
ORGANISM(S): Mus musculus (Mouse) 
2022-01-28 | PXD029318 | Pride
Erastin Hemin Tmt U0126 Ferroptosis Phosphorylation 
GenomicsRNA-seq Analysis of Prostate Cancer Cell Under Erastin Exposure
RNA-seq Analysis of Prostate Cancer Cell Under Erastin Exposure
PRJNA970681 | ENA
TranscriptomicsRNA-seq of human pancreatic cancer cell line PANC-1 treated with RSL-3, N6F11, Fin56 and Erastin against untreated controls
Ferroptotic cell death is dependent on unrestricted lipid peroxidation rather than activation of apoptotic effector caspases. A large number of ferroptosis activators have been reported recently. We used gene sequencing to analyze the effects of four ferroptosis activators (RSL3, N6F11, Fin56 and Er...
ORGANISM(S): Homo sapiens 
2023-10-18 | E-MTAB-12241 | biostudies-arrayexpress
GenomicsThe effects of Erastin on the proliferation of Staphylococcus aureus in mouse macrophages
The effects of Erastin on the proliferation of Staphylococcus aureus in mouse macrophages
PRJNA1130867 | ENA
GenomicsEffect of vitamin K on gene expression in erastin induced ARPE-19 cells.
Effect of vitamin K on gene expression in erastin induced ARPE-19 cells.
PRJNA1109819 | ENA
TranscriptomicsRNA-seq Analysis of Prostate Cancer Cell Under Erastin Exposure
In order to investigate which genes with different expression in prostate cancer(PCa) cells(LNCaP and PC3) after erastin exposure, and identify the essential ferroptosis related genes (FRGs) associated with ferroptosis in PCa cell. 5.0µM erastin was added in cell medium, and we performed gene expres...
ORGANISM(S): Homo sapiens 
2023-09-12 | GSE232034 | GEO
ProteomicsProteomic shift in mouse embryonic fibroblasts Pfa1 during erastin-induced ferroptosis
This report provides data on ferroptosis induced proteomic response in immortalized mouse embryonic fibroblasts which are 4-OH-TAM-inducible Gpx4−/− (referred to as Pfa1 cells). Pfa1 cells are a valuable, widespread and well characterized model for ferroptosis research. In the first part of this ba...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-11 | PXD041463 | Pride
Proteomics Ferroptosis Mouse embryonic fibroblasts Erastin Glutathione peroxidase 4 Liproxtatin-1 Pfa1 Cell death 
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