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MetabolomicsArsenic induces metabolome remodeling in mature human adipocytes
Human lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the deve...
2025-05-23 | MTBLS8808 | MetaboLights
TranscriptomicsGenome-wide analysis of serum starved prelamin A-accumulating hMSCs gene expression.
Analysis of serum starved prelamin A-accumulating hMSCs at gene expression level. The hypothesis tested in the present study was that prelamin A accumulation induces the dysregulation of genes that are essensial for cell survival under a stress condition such as serum starvation. The results provide...
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-52563 | biostudies-arrayexpress
ProteomicsProteomic profiling of human mesenchymal stem cells derived from umbilical cord or adipose tissue
We performed a proteomic profiling of human mesenchymal stem cells (hMSCs) derived from adipose tissue or umbilical cord.
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009893 | Pride
Adipose tissue Human mesenchymal stem cells Hmscs Umbilical cord 
MetabolomicsCadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes
Obesity is considered as a major public health concern with strong economic and social burdens. Exposure to pollutants such as heavy metals can contribute to the development of obesity and its associated metabolic disorders, including type 2 diabetes and cardiovascular diseases. Adipose tissue is an...
2023-06-29 | MTBLS4128 | MetaboLights
TranscriptomicsLactate influences the gene expression profile of human mesenchymal stem cells (hMSC) in a dose dependent manner
Wounds, especially non healing wounds are characterised by elevated tissue lactate concentrations. Lactate is known for being able to stimulate collagen synthesis and vessel growth. Lately it has been shown that lactate, in vivo, plays an important role in homing of stem cells. With this work we aim...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-40205 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells reveals carcinoma associated fibroblast like differentiation
Carcinoma associated fibroblasts (CAFs) have recently been implicated in important aspects of epithelial solid tumor biology such as neoplastic progression, tumor growth, angiogenesis, and metastasis. However, neither the source of CAFs nor the differences between CAFs and fibroblasts from non-neopl...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9764 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mesenchymal stem cells (MSC) maintained in FCS vs autologous serum analysed at passage 4
The purpose of this study was to determine whether the serum condition affected the gene expression in mesenchymal stem cells (MSCs). To that end, we compared gene expression in MSCs maintained in regular growth medium supplemented with fetal calf serum (FCS) with gene expression of MSCs cultured in...
ORGANISM(S): Homo sapiens 
2004-12-08 | E-MEXP-214 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mesenchymal stem cells (MSC) maintained in FCS or autologous serum over time analysed at passage 4 and 10
The purpose of this study was to determine whether the serum condition affected the gene expression in mesenchymal stem cells (MSCs)over time. To that end, we compared gene expression in MSCs maintained in regular growth medium supplemented with fetal calf serum (FCS) for 10 passages with gene expre...
ORGANISM(S): Homo sapiens 
2004-12-08 | E-MEXP-215 | biostudies-arrayexpress
GenomicsATF4 Licenses C/EBPb Activity in Human Mesenchymal Stem Cells Primed for Adipogenesis
We report ChIP-seq for C/EBPb and ATF4 in human mesenchymal stem cells and in a cell-free system using naked genomic DNA. ChIP-Seq for GR, RNA Polymerase II, and H3K27 acetylation in hMSCs cultured under different adipogenic conditions are also presented. hMSCs cultured at high or low cell seeding d...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-68864 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human WhartonM-bM-^@M-^Ys jelly stem cells
Human WhartonM-bM-^@M-^Ys jelly stem cells (hWJSCs) are derived ethically in large amounts from the umbilical cord matrix. Besides their differentiation capabilities, WJSCs also display a notable lack of ability to form teratoma. hWJSCs have been shown to exert immunomodulatory effects and have rece...
ORGANISM(S): Homo sapiens 
2010-07-25 | E-GEOD-20126 | biostudies-arrayexpress
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