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ProteomicsHigh-resolution mass spectrometry for identifying phosphorylation sites of the metabotropic glutamate receptor mGlu3
Metabotropic glutamate receptors (mGlus) modulate synaptic transmission in the central nervous system, while β-arrestins (βarrs) mediate the desensitization and internalization of activated mGlus. We report two structures of the metabotropic glutamate receptor subtype 3 (mGlu3) coupled to βarr1 with...
ORGANISM(S): Homo sapiens (Human) 
2025-02-25 | PXD059170 | Pride
Lc-msms Membrane protein Human mglu3 Purified protein complex 
UnknownmGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data.
Not available
S-EPMC10193767 | biostudies-literature
UnknownMetabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.
Not available
S-EPMC5145804 | biostudies-literature
UnknownFrontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors.
Not available
S-EPMC8505649 | biostudies-literature
TranscriptomicsAge-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
The molecular basis of complex neuropsychiatric disorders most likely involves many genes. In recent years, specific genetic variations influencing risk for schizophrenia and other neuropsychiatric disorders have been reported. We have used custom DNA microarrays and qPCR to investigate the expressi...
ORGANISM(S): Homo sapiens 
2008-05-23 | E-GEOD-11546 | biostudies-arrayexpress
UnknownPreclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson's disease.
Not available
S-EPMC11700162 | biostudies-literature
UnknownGroup II metabotropic glutamate receptor blockade promotes stress resilience in mice.
Not available
S-EPMC6785136 | biostudies-literature
UnknownPreclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia.
Not available
S-EPMC6743422 | biostudies-literature
TranscriptomicsExpression data from normal adrenal gland and aldosterone-producing adenoma
The source of aldosterone in 30 to 40 % of patients with primary hyperaldosteronism (PA) is unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated aldosterone production in APA are unknown. Herein, we examined expression of G-protein coupled receptors (GPCR) in APA and demon...
ORGANISM(S): Homo sapiens 
2007-07-18 | E-GEOD-8514 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced neuronal death
AMPA receptors are involved not only in neuronal plasticity but also in excitotoxicity, mediated largely by the influx of Ca2+ (Choi et al., 1988). Their implication has been highlighted in animal models of ischemia and epilepsy. Studies of ischemic rodent models featured that prior to cell death, h...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22993 | biostudies-arrayexpress
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