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TranscriptomicsExpression data from MOLM-14 human acute myeloid leukemia cell line after mTORC1 inhibition by rapamycin
The objective of the sudy is to evalute the role of mTORC1 signalling in the regulation of the metabolism of MOLM-14 cells. We used microarrays to investigate gene expression in MOLM-14 cells after down-regulation of mTORC1 signalling by rapamycin.
ORGANISM(S): Homo sapiens 
2017-08-14 | GSE95172 | GEO
UnknownEIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.
Not available
S-EPMC9733142 | biostudies-literature
ProteomicsExtracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche
To understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) ...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD013688 | Pride
Aml-derived extracellular vesicles Isobaric labeling Proteomics Bone marrow Acute myeloid leukemia (aml) Mouse Tandem mass tags 
GenomicsHomo sapiens
Expression data from MOLM-14 human acute myeloid leukemia cell line after mTORC1 inhibition by rapamycin
PRJNA376267 | ENA
Proteomics: Robust and reproducible large-scale label-free deep quantitative profiling of the MOLM-14 surfaceome using three mass spectrometry platforms over multiple years
Surface proteins are one of the most important and common matrices for clinical chemistry and proteomic analyses. With the rapid developments in mass spectrometry (MS)-based proteomics methods, label-free quantitative proteomics has become an increasingly popular tool for profiling global protein ab...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD022721 | Pride
Quantitative proteomics Reproducibility Label-free quantification Mass spectrometry Surfaceome Large-scale 
ProteomicsHuman acute myeloid leukemia (AML) cell line LFQ, comparison between doxycycline-inducible control shRNA and Pim2 shRNA
Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20-30% of AML cases. This subtype usually responds poorly to conventional therapies including FLT3 tyrosine kinase inhibitors (TKIs) due to molecular bypass mechanisms. New therapeutic strategies are t...
ORGANISM(S): Homo sapiens (Human) 
2017-09-18 | PXD005880 | Pride
Aml Rna interference Pim2 Lfq 
TranscriptomicsIn Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
We used an in vivo short hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo, and for human leukemia cells in xenotransplantation studies.M-BM- In l...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-46302 | biostudies-arrayexpress
GenomicsHomo sapiens
Expression data from MOLM-14 human acute myeloid leukemia cell line after AMPK activation by GSK621 according to mTORC1 activation level
PRJNA282029 | ENA
TranscriptomicsGSK-3A and GSK-3B knockdown in AML cell lines
Gene expression data from AML cell lines, MOLM-14, U937, THP-1 and HL-60, that were infected with a scrambled control hairpin (shControl), two shRNAs directed against GSK-3B (shGSK3B_1 and shGSK3B_2), or two shRNAs directed against GSK-3A (shGSK3A_5 and shGSK3A_6). Acute myeloid leukemia (AML) is th...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-35200 | biostudies-arrayexpress
TranscriptomicsSYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia
Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify collabora...
ORGANISM(S): Homo sapiens 
2014-01-15 | E-GEOD-54065 | biostudies-arrayexpress
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