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TranscriptomicsTranscription profiling of rat nasal respiratory and olfactory epithelium
The nasal epithelium is an important target site for chemically-induced toxicity and carcinogenicity. Human epidemiological investigations and experimental laboratory animal studies show that the nasal olfactory epithelium is selectively damaged by inhalation exposure to several chemicals, includin...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5019 | biostudies-arrayexpress
TranscriptomicsGene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.
mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in b...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-16008 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of nasal polyp derived human IL17RB positive and negative T-helper cells
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in western countries is characterized by eosinophilia, IgE production and Th2 cytokine expression. Type 2 innate lymphoid cells (ILC2) from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33 although the relevance of this axi...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-70898 | biostudies-arrayexpress
GenomicsTranscriptome human nasal epithelium
1. Odors are detected, firstly, by olfactory sensory neurons (OSNs) in the olfactory epithelium of the nose. This neurons then project directly to the olfactory bulb in the brain. Olfaction depends on cellular regeneration of the OE, olfactory bulb and hippocampus, and on their continual re-wiring. ...
EGAS00001001294 | EGA
Transcriptomics3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product (nasal epithelial cells-microRNA dataset).
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2018-04-01 | E-MTAB-6613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary nasal epithelium exposed to house dust mite extract shows activated expression in allergics
Response to allergen was studied in epithelial cells derived from allergic pantients and from healthy controls. Cells were cultured after isolation from a nasal biopsy. Cells were exposed to Housed dust mite or vessel (saline); Microarray data was analysed using bioinformatics and biostaistics. We c...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9150 | biostudies-arrayexpress
TranscriptomicsGene regulation by Sox9 in the conjunctival epithelium
Wild type or Sox9 fx/fx; Le-Cre-positive (Sox9-/-) conjunctival epithelium from the temporal, nasal and dorsal region of E14.5 mouse embryos was laser micodissected from three embryos of each genotype. Total RNA was purified and reverse transcribed and amplified using a NuGEN kit. cDNA was biotinyla...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-54796 | biostudies-arrayexpress
ProteomicsIn depth proteome analyais of primary human nasal epithelium induced by diesel exhaust particles
Diesel exhaust particles (DEPs), a major component of airborne particulate matter (PM), are strongly associated with the development of both acute and chronic upper airway inflammatory diseases. In this study, we investigated the effects of prolonged daily exposure to low-dose DEPs on the maturation...
ORGANISM(S): Homo sapiens (Human) 
2026-05-23 | PXD065940 | Pride
Diesel exhaust particles Human nasal epithelium Tmt 
ProteomicsPhosphoproteome of SARS-CoV-2 infected Human Nasal Epithelium
The nasal epithelium is the primary initial site of SARS-CoV-2 entry in the human body. Since much of the molecular detail defining coronavirus entry and replication was derived from non-nasal cell lines, it remains unclear how SARS-CoV-2 overcomes the physical nasal mucus and periciliary mucin laye...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028123 | Pride
Sars-cov-2 Human nasal epithelium Phosphoproteome 
TranscriptomicsTranscription profiling of murine olfactory epithelium during neuronal death and replacement to study adult neurogenesis in the olfactory epithelium
Expression profiling of mRNA abundance in the adult mouse olfactory epithelium during replacement of OSNs forced by the bilateral ablation of the olfactory bulbs. The experiment was done on 6 week old male C57Bl/6 mice. Olfactory epithelium tissue samples were collected on days 1, 5, and 7 after b...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2437 | biostudies-arrayexpress
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