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MetabolomicsMulti-omic Landscape of Airway Microbe-Host Interactions in Chronic Obstructive Pulmonary Disease

The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of airway microbe-host interactions in COPD by an in-depth profiling of sputum metagenome, metabolome, host transcriptome and proteome from 99 COPD pati...

2022-06-20 | MTBLS4017 | MetaboLights
TranscriptomicsEffects of Myb shRNA on Airway Epithelial Cells
The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63+ basal ep...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60365 | biostudies-arrayexpress
TranscriptomicsAirway Epithelial miRNA Expression in Asthma
We performed genome-wide profiling of miRNA expression in the airway epithelial compartment in asthma to identify miRNA pathways associated with epithelial abnormalities using miRNA microarrays and real-time PCR. We also sought to identify the effect of inhaled corticosteroids (ICS) on airway epithe...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-34466 | biostudies-arrayexpress
TranscriptomicsComparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment (small airway epithelial cells-microRNA dataset)
The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for the first time in vitro using human small airway and nasal epithelial models following a systems toxicology approach. The potentially reduce...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-6611 | biostudies-arrayexpress
TranscriptomicsComparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment (small airway epithelial cells-mRNA dataset)
The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for the first time in vitro using human small airway and nasal epithelial models following a systems toxicology approach. The potentially reduce...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-6610 | biostudies-arrayexpress
TranscriptomicsGene Expression Effects of IL-13 on Primary Human Airway Epithelial Cells
Primary culture airway epithelial cells, grown under physiologic air-liquid interface conditions, with, or without IL-13 in order to study the effects of this cytokine on mucous cell metaplasia, an important feature of asthma and COPD. Keywords: IL13, mucus, goblet cell RNA was isolated from primary...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-37693 | biostudies-arrayexpress
TranscriptomicsPost-exposure effect of whole cigarette smoke on in vitro 3D human airway epithelial tissues from large and small epithelial cells
Chronic obstructive pulmonary disease (COPD) is a disease state characterized by poorly reversible, limited airflow that is usually both progressive and associated with an abnormal inflammatory response of the lung. One cause of COPD is chronic exposure to airborne materials such as cigarette smoke ...
ORGANISM(S): Homo sapiens 
2020-12-24 | E-MTAB-8680 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomics of epithelial mesenchymal transition of human primary small airway epithelial cells
A study employs quantitative phosphoproteomics approch for systems biology understanding of epithelial mesenchymal transition of human primary small airway epithelial cells
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003296 | Pride
Phosphoproteomics Human primary small airway epithelial cells Epithelial mesenchymal transition 
ProteomicsQuantitative phosproteomics of epithelial mesenchymal transition of human primary small airway epithelial cells
A study employs quantitative phosphoproteomics approach fro systems biology understanding of the epithelial mesenchymal transition of human primary small airway epithelial cells.
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003297 | Pride
Lc-ms Epithelial mesenchymal transition Human primary small airway epithelial cells 
TranscriptomicsPhenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus
We report the application of RNA sequencing technology for high-throughput profiling of gene expression responses to human rhinovirus infection at 24 hours in air-liquid interface human airway epithelial cell cultures derived from 6 asthmatic and 6 non-asthmatic donors. RNA-seq analysis identified ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-61141 | biostudies-arrayexpress
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