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TranscriptomicsExpression data from human induced pluripotent stem cells derived retinal pigment epithelium (hiPSC-RPE)
We generated hiPSCs from patients fibloblast with retinitis pigmentosa (RP) using retrovirus and Sendai virus vectors, which we differentiated into hiPSC derived retinal pigment epithelium using two different methods (SDIA and SFEB methods). We investigated whether these hiPSC-RPE colonies, which we...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-50738 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis and Molecular Signature of Human Retinal Pigment Epithelium
The retinal pigment epithelium (RPE) is a polarized cell layer that is critical for photoreceptor function and survival. It’s unique relationship to the photoreceptors and its specific physiology makes the RPE a critical determinant of human vision. Therefore we performed global expression profil...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-18811 | biostudies-arrayexpress
TranscriptomicsRPE Redifferentiation (miRNA)
Retinal Pigment Epithelial (RPE) cells are located behind the retina and are critical for photoreceptor survival. Loss of RPE is associated with several pathogenic conditions such as Age Related Macular Degeneration and Retinitis Pigmentosa. RPE derived from human embryonic stem cells (hESC) offer a...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-960 | biostudies-arrayexpress
TranscriptomicsCharacterization of hES derived Retinal Pigment Epithelial (RPE). RPE proliferation involves a non-classical Epithelial-Mesenchymal Transition (EMT).
Retinal Pigment Epithelial (RPE) cells are located behind the retina and are critical for photoreceptor survival. Loss of RPE is associated with several pathogenic conditions such as Age Related Macular Degeneration and Retinitis Pigmentosa. RPE derived from human embryonic stem cells (hESC) offer a...
ORGANISM(S): Homo sapiens 
2012-10-24 | E-MTAB-854 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human iPSC-derived Retinal Pigmented Epithelial (RPE) cells from LCA patients and unaffected persons
Our purpose was to investigate genes and molecular mechanisms involved in patients with Leber congenital amaurosis (LCA). Fibroblasts from two unrelated clinically-identified patients (Coriell) were reprogrammed to pluripotency by retroviral transduction. These human induced Pluripotent Stem Cells (...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-43926 | biostudies-arrayexpress
ProteomicsThe proteome of normal human iris, ciliary body, retinal pigment epithelium, and choroid
The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-29 | MSV000081766 | MassIVE
GenomicsIntegrated analysis of DNA methylation and RNA transcriptome during the differentiation of human pluripotent stem cells into retinal pigment epithelial cells
Using the paradigm of in vitro differentiation of hESCs/iPSCs into retinal pigment epithelial (RPE) cells, we have recently profiled mRNA and miRNA transcriptomes to define a set of RPE mRNA and miRNA signature genes implicated in directed RPE differentiation. In this study, in order to understand t...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-43473 | biostudies-arrayexpress
ProteomicsN-terminomic analysis of RPE secretome
Identification of HtrA1 substrate in the context of RPE secretome
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007139 | Pride
Human rpe Htra1 
MetabolomicsMulti-omic profiles of human nonalcoholic fatty liver disease tissue highlight heterogenic phenotypes
Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms in, e.g. APOC3, ...
2015-12-07 | MTBLS174 | MetaboLights
ProteomicsHuman RPE LC-MSMS
AMD is a complex disorder related to environmental factors and genetic polymorphisms. We explored the interplay between the two factors by comparing the differences between HTRA1/ARMS2 high-risk and low-risk AMD alleles after exposure to smokers’ serum using iTRAQ-based proteomics. Primary human ret...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD009309 | Pride
Human Lc-msms Retinal Rpe 
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