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MetabolomicsUntargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men: A noninvasive detection of spermatogenesis
Male factor infertility is involved in almost half of all infertile couples. Lack of the ejaculated sperm owing to testicular malfunction has been reported in 6-10% of infertile men, a condition named nonobstructive azoospermia (NOA). In this study, we investigated untargeted metabolomic profiling o...
2018-04-19 | MTBLS420 | MetaboLights
MetabolomicsDeciphering metabolomic alterations in seminal plasma of crossbred (Bos taurus X Bos indicus) bulls through comparative deep metabolomic analysis
The incidence of sub-fertility is higher in crossbred bulls compared to zebu bulls. In the present study, we analysed the metabolomic profile of seminal plasma from crossbred and zebu bulls and uncovered differentially expressed metabolites between these two breeds. Using a high-throughput LC-MS/MS-...
2021-12-22 | MTBLS1642 | MetaboLights
MetabolomicsSeminal lipid depletion and gut microbiome–metabolome alterations in men with gonadotropin-treated idiopathic hypogonadotropic hypogonadism: an integrated multi-omics study
This study investigated seminal plasma lipid alterations and gut microbiome–metabolome changes in men with gonadotropin-treated idiopathic hypogonadotropic hypogonadism. Seminal plasma metabolomics, fecal metagenomic sequencing, and fecal metabolomics were performed in patients and healthy controls....
2026-07-20 | MTBLS15080 | MetaboLights
TranscriptomicsSeminal plasma and transforming growth factor-β regulate gene expression in human Ect1 ectocervical epithelial cells
In this study we examined the influence of seminal plasma on gene expression in human Ect1 ectocervical epithelial cells, and the extent to which recombinant TGFβ3 elicits comparable changes. Ect1 cells were incubated with recombinant human TGFβ3 (5 ng/ml), 10% pooled human seminal plasma (v/v), or ...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-35830 | biostudies-arrayexpress
TranscriptomicsSystematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility
Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles of seminal plasma piRNAs in infertile males to identify piRNAs that are altered during infe...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-78131 | biostudies-arrayexpress
MetabolomicsMetabolomic analysis of seminal fluids in oligoasthenospermia individuals

In this study, we systematically characterized the metabolic signatures of oligoasthenospermia individuals and health controls using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Additionally, we performed functional validation of specific differential metabolites ...

2025-07-14 | MTBLS12711 | MetaboLights
ProteomicsN-linked glycoproteome of human seminal plasma
N-linked glycosylation is an important type of post-translational modification. This modification plays important roles in many cellular functions including cell-cell and receptor-ligand interactions, immune response, apoptosis, and pathogenesis of many diseases. Seminal plasma is a mixture of secre...
ORGANISM(S): Homo sapiens (Human) 
2014-12-15 | PXD000959 | Pride
Lc-ms/ms Seminal plasma Glycoproteome Human 
MetabolomicsRefining the seminal biomarker detection: metabolome profiles before and after the liquefaction procedure
Semen metabolome analysis presents a promising approach to identify potential biomarkers. However, it remains unclear whether metabolites should be analyzed immediately from fresh ejaculate or after the liquefaction process in conjunction with routine semen quality assessments. To address this quest...
2025-04-02 | MTBLS11207 | MetaboLights
OtherSeminal plasma proteome of ram and impact on semen liquid preservation.
Data from ProteomeXchange, PXD ID: PXD000822. File: 11-2809_Druart_PSB_27_ORBI105.mzML. Published as part of J Proteomics. 2014 Jul 15;109C:245-260 . From the Abstract: {{i}} Seminal plasma is composed of secretions from the epididymis and the accessory sex glands and plays a critical role in the f...
ORGANISM(S): Sheep_e 
GPM32310003162 | GPMDB
Resource Reanalysis 
TranscriptomicsMating and sperm free seminal plasma changes gene expression in the oviductal sperm reservoirs of sows
Sperms being foreign to the female are to be promptly eliminated by the female local immune defense. However, avoiding the local immune defense sperm can be stored for lenthy period in the oviductal sperm reservoir. It is currently unknown whether oviductal sperm reservoirs changes their gene expres...
ORGANISM(S): Sus scrofa 
2016-06-23 | E-GEOD-83622 | biostudies-arrayexpress
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