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MetabolomicsA Metabonomic Comparison of Human Serum and Plasma Subtypes Using Untargeted NMR Spectroscopy and UPLC-MS (NMR assays)
INTRODUCTION: Differences in the metabolite profiles between serum and plasma are incompletely understood. OBJECTIVES: To evaluate metabolic profile differences between serum and plasma and among plasma sample subtypes. METHODS: We analyzed serum, platelet rich plasma (PRP), platelet poo...
2018-07-25 | MTBLS470 | MetaboLights
ProteomicsQuantification of isoaspartate levels in human serum albumin of blood samples
We measured the isoaspartate levels in human serum albumin of blood samples from 20 patients with Alzheimer's disease and 20 healthy controls.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027563 | Pride
Mass spectrometry Isoaspartate Human serum albumin Alzheimer's disease 
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
ProteomicsQuantification of glycated human serum albumin peptides
Human serum albumin is the most abundant plasma protein with a large number of lysine and arginine residues. Hence, it is highly susceptible to glycation in vivo. In hyperglycemic conditions, such as diabetes, the level of HSA glycation increases. Here we quantified glycated HSA peptides in a subjec...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040028 | Pride
Glycation Mass spectrometry Human serum albumin Hba1c Plasma Microalbuminuria Kidney Homo sapiens 
ProteomicsDefining albumin as a glycoprotein with multiple N-linked glycosylation sites
Background Plasma proteins can be modified by addition of sugar residues by non-enzymatic glycation as well as glycosylation. While glycation is a hallmark of hyperglycemia, glycosylation is a complex, enzyme-catalyzed post-translational modification by heterogeneous sugar chains and is present on ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2024-06-16 | PXD047863 | Pride
Microheterogeneity Glycoproteomics Novel glycosylation site Hsa Human serum albumin Bsa 
MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
ProteomicsIn-depth proteome analysis of Hela cell culture conditioned media containing fetal bovine serum.
We performed DIA-MS based proteomic analysis of Hela cells conditioned media containing fetal bovine serum by albumin (Alb)-depletion and non-depletion. In addition, we attempted to enrich secreted proteins by reducing the volume of culture medium (10mL, 5mL and 2mL). The supernatants of each cultur...
ORGANISM(S): Homo Sapiens (human) 
2022-02-22 | PXD024272 | JPOST Repository
ProteomicsProtein Structure Determination in Biological Matrices by Mass Spectrometry and Computational Biology
We have implemented the use of a heterobifunctional, UV photoactivatable cross-linker, which greatly increases the number of identified cross-links compared with homobifunctional, NHS-ester based cross-linkers. We have cross-linked human serum albumin in the context of human blood serum. We present ...
ORGANISM(S): Homo sapiens (Human) 
2015-09-22 | PXD001692 | Pride
Cross-linking and mass spectrometry Human serum albumin 
MetabolomicsNMR-based metabolomic profile of hypercholesterolemic human sera: Relationship with in vitro gene expression?
Hypercholesterolaemia is considered an important cause of atherosclerotic cardiovascular disease. In a previous investigation, we demonstrated that cultured hepatoma cells treated with hypercholesterolaemic sera compared with cells treated with normocholesterolaemic sera show overexpression of mRNAs...
2020-05-26 | MTBLS1416 | MetaboLights
TranscriptomicsTranscription profiling by array of human endothelial cell monolayers treated with homocysteinylated albumin
Endothelial cells monolayers were incubated, for 18h, in the presence of 1.0 ?M N-homocysteinylated albumin. Negative controls were cells incubated with unmodified human serum albumin at a comparable protein concentration and untreated cells.
ORGANISM(S): Homo sapiens 
2011-06-07 | E-MEXP-2771 | biostudies-arrayexpress
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