Sort   by:  
 Page size 
MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
MetabolomicsDifferentially manufactured Arnica montana L. extracts mediate anti-inflammatory effects on human T cells via different signaling pathways

Arnica montana L. (Arnica) has a long history of use in treating inflammation and soft tissue injury, yet its immunomodulatory mechanisms remain largely unexplored. In this study, we investigated the effects of distinct Arnica extracts - derived from different plant parts (root or whole ...

2025-09-16 | MTBLS11351 | MetaboLights
MetabolomicsMetabolome analysis reveal key regulatory pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense

A total of 445 and 247 differently expressed metabolites (DEMs) were identified in the hepatopancreas and muscle. In addition, 11 KEGG pathways, which mainly include lysine biosynthesis, lysine degradation, aminoacyl-tRNA biosynthesis and purine metabolism, were sign...

2023-02-28 | MTBLS6663 | MetaboLights
TranscriptomicsGene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies have considerable drawbacks and fail to replace the normal disc in facilitating spinal movements a...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-70362 | biostudies-arrayexpress
TranscriptomicsDissecting the signalling pathways underlying cellular senescence
Cellular senescence is a program of irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress. The underlying signalling pathways, potentially of major clinicopathological rele...
ORGANISM(S): Homo sapiens 
2011-01-21 | E-GEOD-24810 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of alternative splicing regulation by insulin and wingless signalling in Drosophila cells
Background: Despite the prevalence and biological relevance of both signalling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signalling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis of changes in alternative splicing...
ORGANISM(S): Drosophila melanogaster 
2010-05-06 | E-GEOD-14085 | biostudies-arrayexpress
TranscriptomicsLarge-scale profiling of intracellular signalling pathway activation reveals major distinctions between airway smooth muscle cells of asthmatics and non-asthmatics.
Signalling pathways regulate all major cellular events in health and disease, including asthma development and progression. Complexity of human intracellular signalization can be explored using novel systemic approaches that exploit whole-transcriptome analysis. Cap-analysis-of-gene-expression (CAGE...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-63744 | biostudies-arrayexpress
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
TranscriptomicsSeminal plasma and transforming growth factor-β regulate gene expression in human Ect1 ectocervical epithelial cells
In this study we examined the influence of seminal plasma on gene expression in human Ect1 ectocervical epithelial cells, and the extent to which recombinant TGFβ3 elicits comparable changes. Ect1 cells were incubated with recombinant human TGFβ3 (5 ng/ml), 10% pooled human seminal plasma (v/v), or ...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-35830 | biostudies-arrayexpress
MetabolomicsIntegration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in pulmonary tuberculosis and pulmonary tuberculosis-complicated diabetes

Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that threaten human health. Patients with DM are susceptible to PTB, an important factor that aggravates the complications of diabetes. However, the molecular regulatory mechanism underlying the susceptibility of ...

2023-07-26 | MTBLS7623 | MetaboLights
Sort   by:  
 Page size