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MetabolomicsA multi-omics dataset of heat-shock response in the yeast RNA binding protein Mip6 (NMR assay)

Gene expression is a biological process regulated at different molecular levels, including chromatin accessibility, transcription, and RNA maturation and transport. In addition, these regulatory mechanisms have strong links with cellular metabolism. Here we present a multi-omics dataset that capt...

2020-02-14 | MTBLS1320 | MetaboLights
TranscriptomicsWidespread regulation of translation by elongation pausing in heat shock
RNA-seq and ribosome footprinting libraries of mouse 3T3 and human 293T cellsrelated to Shalgi et al. 2013 36bases paired-end RNA-seq, and ribosome footprinting libraries for: 3T3 cells - Control, 8 hours of mild heat shock (42) and 2 hours of severe heat shock (44) - in replicates, as well as 3T3 ...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-32060 | biostudies-arrayexpress
MetabolomicsAcute heat stress amplifies exercise-induced metabolomic perturbations and reveals variation in circulating amino acids in endurance-trained males

Using untargeted metabolomics, we aimed to characterise the systemic impact of environmental heat stress during exercise. Twenty-three trained male triathletes completed a 30-min exercise test in hot (35°C) and temperate (21°C) conditions. Venous blood samples were collected immediately pre- and ...

2025-08-14 | MTBLS6051 | MetaboLights
MetabolomicsExploring the variations in intestinal microbial communities and metabolite profiles between heat-sensitive and heat-tolerant chickens through a comprehensive multi-omics approach

Heat stress (HS) compromises poultry health by disrupting intestinal integrity and microbiota homeostasis. This study compared heat stress-susceptible (HS-SUS) and heat stress-resistant (HS-RES) White Leghorn chickens under chronic cyclic HS (35±2°C, 8 h/day). HS-RES chickens demonstrated superio...

2025-09-12 | MTBLS12991 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis HsfA2 knockout plants response to heat shock
The expression of heat-shock proteins (Hsps) induced by a non-lethal heat treatment confers acquired thermotolerance (AT) to organisms against a subsequent challenge of otherwise lethal temperature. After stress signal lifted, AT gradually decayed with the decline of Hsps during recovery period. The...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-4760 | biostudies-arrayexpress
Genomicsheat shock SUMO-2 ChIP-seq
Analysis of changes in SUMO-2 binding to chromatin in response to heat shock in human U2OS cells
ORGANISM(S): Homo sapiens 
2015-07-13 | E-MTAB-2368 | biostudies-arrayexpress
TranscriptomicsGene expression microarray analysis of heat stress in the soil invertebrate Folsomia candida
Temperature is an important ecological condition, and sudden temperature changes in soil can induce stress in soil-dwelling invertebrates. Soil animals can move to more favorable habitats and/or adapt physiologically to a stressful environment. Hyperthermic conditions will impact gene expression as ...
ORGANISM(S): Folsomia candida 
2010-06-24 | E-GEOD-17024 | biostudies-arrayexpress
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
ProteomicsSmall heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Mitochondria are complex organelles with different compartments, each harboring their own protein quality control factors. While the chaperones of the mitochondrial matrix have been well characterized, it is poorly understood which chaperones protect the mitochondrial intermembrane space. We show th...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD038275 | Pride
Charcot-marie-tooth (cmt) disease Protein quality control Intermembrane space Small heat shock proteins Mitochondria Chaperones 
ProteomicsAPEX2-proximity labelling of small heat shock protein condensates and aggregates
Small heat shock proteins are chaperones that are essential in preserving the integrity of the cellular proteome during stress conditions. The human genome encodes ten small heat shock proteins (HspB1-HspB10), which often form polydisperse multimeric functional structures. Uniquely, HspB2 and HspB3 ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-20 | PXD035040 | Pride
Human Hspb2 Apex2 Hek293t cells Protein aggregation Proximity labelling Liquid-liquid phase separation Small heat shock protein Hspb5 
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