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ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-05 | PXD031129 | JPOST Repository
ProteomicsProperties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytes
The templated misfolding of tau proteins accounts for tau pathology spread in Alzheimer’s disease (AD). Post-translational modifications, including phosphorylation at specific residues, are closely linked with tau seeding ability and clinical disease progression. This study investigates the role of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056614 | Pride
Tau  alzheimer’s disease  astrocyte 
ProteomicsIdentification of novel kinases of Tau using fluorescence complementation mass spectrometry (FCMS)
Hyperphosphorylation of the microtubule-associated protein Tau is a major hallmark of Alzheimer’s disease (AD) and other tauopathies. Understanding the protein kinases that phosphorylate Tau is critical for the development of new drugs that target Tau phosphorylation. At present, the repertoire of t...
ORGANISM(S): Homo Sapiens (human) 
2022-11-10 | PXD036956 | JPOST Repository
ProteomicsPathogenic human tau in the Line 66 model of frontotemporal dementia
Transgenic human tau in subcellular fractions extracted after electrophoresis of L66 mouse brain extract. For higher sequence coverage trypsin (Tr) and thermolysin (TL) digests were analysed.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-08-13 | MSV000085945 | MassIVE
ProteomicsTruncated Tau
Tau is a microtubule-associated protein that ensures neuronal shape and function. Besides, Tau is a central player in Alzheimer’s disease (AD) and related Tauopathies where it is found aggregated in degenerating neurons. Mechanisms leading to Tau pathology and its progression are far from being eluc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-27 | MSV000081020 | MassIVE
ProteomicsDistribution of big tau isoforms in the human central and peripheral nervous system
‘Big tau’, a longer isoform of tau is expressed in peripheral nervous system (PNS) and specific regions of the central nervous system (CNS). Big tau distribution across the human nervous system and pathophysiological role remains largely unknown. Here, using mass spectrometry, we demonstrate the big...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059267 | Pride
Tau protein Nerve Proteomics Brain Alzheimer's disease Spinal cord Lc-ms/ms 
ProteomicsPhosphorylated Tau Interactome in the Human Alzheimers Disease Brain
Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-17 | MSV000085305 | MassIVE
ProteomicsThe interactome of tau phosphorylated at T217 in Alzheimers disease human brain tissue
Tau phosphorylation and aggregation are pathological features of Alzheimers disease. Tau phosphorylated at threonine 217 (pT217) and threonine 231 (pT231) are early fluid biomarkers of Alzheimers disease, suggesting early involvement in disease. However, little is known about the specific actions of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-11 | MSV000096377 | MassIVE
ProteomicsAnalysis of pathological tau associated with a wide range of tauopathies
We have analyzed and compared the post-translational modifications in the pathological tau proteins prepared from a wide range of tauopathies.
ORGANISM(S): Homo Sapiens (human) 
2020-07-15 | PXD020371 | JPOST Repository
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - MC1-isolated Tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088408 | MassIVE
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