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MetabolomicsMetabolomics Analysis of the Effect of GAT-2 Deficiency on Th1 Cells in Mice

The classic neurotransmitter gamma-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3 and GAT-4) responsible for the transmembrane transport of GABA in mice. To explore t...

2021-10-14 | MTBLS3358 | MetaboLights
ProteomicsCompetitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders
In this study, we compared the effects of two cytokine treatments on the proteome of human Th-1 cells. We used saturating doses of murine single-chain IL-27 (EBI3+p28, 10nM) and HyperIL-6 (20nM) and continuously stimulated cells of three donors with the two cytokines for 24h or left untreated.
ORGANISM(S): Homo sapiens (Human) 
2021-05-05 | PXD024188 | Pride
Human th-1 Il-6 Il-27 
TranscriptomicsTranscription profiling of human Treg and Th clones - experiment I
The aim of this work was to identify functional features that are specific of human Treg cells, through the identification of genes that are differentially expressed: 1/ in activated Treg clones versus activated Thelper clones; 2/ in Th clones activated in the presence versus the absence of TGFb; 3/...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-14330 | biostudies-arrayexpress
ProteomicsCompetitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders
In this study, we compared the effects of two cytokine treatments on the proteome of human Th-1 cells. We used saturating doses of murine single-chain IL-27 (EBI3+p28, 10nM) and HyperIL-6 (20nM) and continuously stimulated cells of three donors with the two cytokines for 15min or left untreated.
ORGANISM(S): Homo sapiens (Human) 
2021-05-05 | PXD024657 | Pride
Silac Il-6 Il-27 Phosphoproteomics Th-1 
MetabolomicsHuman milk as infantile Super Food - the effect of dietary choices and supplementation on the shift of lipidomic profile during different stages of lactation
The objective of this project was to establish an advanced analytical method leveraging high-resolution mass spectrometry LC-HRMS to comprehensively profile the human milk lipidome. Mass spectrometry resolves and quantifies compounds based on a fundamental physical metric: the mass-to-charge ratio. ...
2026-09-22 | MTBLS15678 | MetaboLights
UnknownIdentifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis.
Not available
S-EPMC8044715 | biostudies-literature
TranscriptomicsTranscription profiling of mouse Th1 cells after repeated vs. recently reactivation reveals autoregulation of Th1-mediated inflammation by twist1 2nd part
Gene expression profiling of repeatedly activated compared to recently activated Th1 cells to identify genes that play a role in chronic inflammatory disorders and may qualify as diagnostic or therapeutic targets; ; Upon activation under appropriate costimulatory conditions, naive T helper (Th) cell...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11534 | biostudies-arrayexpress
TranscriptomicsThe role of microRNAs in hepatic thyroid hormone signalling
MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-21277 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human Th9 T cell clones treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response of activated “TH9” clones to treatment with GW9662, a potent PPAR-γ antagonist was assessed. “TH9” cell clones were incubated with GW9662 for 48h and activated with αCD3/2/28 for 12 h. Transcriptomic profiling was performe...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12197 | biostudies-arrayexpress
TranscriptomicsProviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation
The aim of the dataset was to study on genome-wide level the effect of PIM kinase (PIM1+PIM2+PIM3) knockdown in gene expression on early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) polarizing conditions. Total RNA from PIM1+PIM2+PIM3 siRNA treated cord bloo...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-40542 | biostudies-arrayexpress
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