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TranscriptomicsInterleukin-27 is a potent inhibitor of cis HIV-1 replication in Monocyte-derived Dendritic Cells via a Type I Interferon-independent pathway
IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-44732 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of mouse group 2 innate lymphoid cells (ILC2s) cultured with IL-33, IFN-g, and IL-27
Purpose: We found that IFN-g and IL-27 had suppressive effects on ILC2s cultured with IL-33. The goal of this study is to clarify the expressions of RNA induced by IFN-g and IL-27 in ILC2s. Methods: ILC2s were isolated from fat-asociated lymphid clusters (FALC) of wild-type mice. They were cultured ...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-73272 | biostudies-arrayexpress
TranscriptomicsGene expression profile for naïve CD4+ T cells after 60-hour-treatment by IL-27
The inhibitory receptor Tim-3 has emerged as a critical regulator of the T cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signaling pathways that drive Tim-3 expression. Here, we demonstrate that IL-27 induces NFIL3, which promotes perm...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-63628 | biostudies-arrayexpress
GenomicsAsymmetry of STAT action in driving IL-27 and IL-6 transcriptional outputs and cytokine specificity
IL-6 and IL-27 have antagonistic and overlapping functions, signal through a shared receptor subunit and employ the same downstream STAT proteins. To evaluate the degree of specificity and redundancy for these cytokines, we quantified global transcriptomic changes induced by the two cytokines and de...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-65621 | biostudies-arrayexpress
TranscriptomicsIL-27 Inhibits HIV-1 Infection in Human Macrophages by Down-regulating Host Factor SPTBN1 during Monocyte to Macrophage Differentiation
The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. Here, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are non-permissive for HIV-1 infe...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-43595 | biostudies-arrayexpress
TranscriptomicsIL-27 stimulation in Foxp3+ Tregs improves suppressive function and therapeutic efficacy
Foxp3 expressing regulatory T cells (Tregs) are the central regulator of immune homeostasis and tolerance. As it is believed that proper Treg function is compromised under inflammatory conditions, exploring a pathway that enhances Treg function is of great importance. In this study, we report that I...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-63455 | biostudies-arrayexpress
TranscriptomicsDistinct roles for IL-27 and IFN-g in the development of T-bet+ Treg required to limit infection-induced pathology
IL-27 is a potent antagonist of TH1-mediated inflammation, but the basis for this effect is not fully understood. Recent studies identified a population of T-bet+ CXCR3+ Treg that limit TH1-mediated immune pathology. The studies presented here demonstrate that IL-27-mediated STAT1 activation promote...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-38686 | biostudies-arrayexpress
ProteomicsProteomic analysis uncovers common effects of IFN-γ and IL-27 on antigen presentation machinery components in human cancer cells
IL-27, a member of the IL-12- family of cytokines, has shown anti-tumor activity in several pre-clinical models due to anti-proliferative, anti-angiogenic and immune-enhancing effects. On the other hand, IL-27 demonstrated immune-regulatory activities and inhibition of auto-immunity in mouse models....
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD004419 | Pride
Antigen presentation machinery. Il-27 Interferon gamma  proteomic analysis  hla class i  apm Interleukin-27  ifn-γ 
TranscriptomicsGenes regulated by IL-27 in intestinal epithelial cells
DLD-1 cells were stimulated with 50 ng/ml for 6 hours.
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MEXP-3336 | biostudies-arrayexpress
GenomicsTreatment of TRAMP-C2-Ras tumors with IL-27 and IL-18 therapies
Treatment of TRAMP-C2-Ras tumors with IL-27 and IL-18 therapies
PRJNA737453 | ENA
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