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MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
TranscriptomicsTranscriptional profiling of THP1-derived human macrophages with different stimuli
Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental clues and depend on highly plastic transcriptional ...
ORGANISM(S): Homo sapiens 
2017-08-25 | E-MTAB-5917 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of primary human macrophages with different stimuli
Primary human macrophages were cultured 1, 3 or 6 days with different stimuli. Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which ar...
ORGANISM(S): Homo sapiens 
2017-08-25 | E-MTAB-5913 | biostudies-arrayexpress
TranscriptomicsTHP1 derived macrophage and foam cell gene expression in presence and absence of T0901317 and RNAi analyses of LXRa/b
To assess the LXRa dependent regulatory pathways in macrophages and foam cells we treated our two, THP1 derived native and LXR-knockdown cell models either with T0901317 or vehicle control (DMSO).
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1106 | biostudies-arrayexpress
TranscriptomicsRNAseq of primary human monocyte derived macrophages (MDM) and differentiated THP-1 macrophages exposed to graphene-related (nano)materials (GRMs)
Occupational and consumer exposure to GRMs will increase but their impact on human health is still largely unknown. We sought to perform a transcriptome comparison of the bioresponses of MDM and THP-1 macrophages exposed to 5 or 20 µg/ml graphene oxide (GO) or graphene nanoplatelets (GNP) for 6 and ...
ORGANISM(S): Homo sapiens 
2023-02-01 | E-MTAB-10099 | biostudies-arrayexpress
GenomicsBulk RNAseq in control and LACTB KD human THP1 macrophages
Bulk RNAseq in control and LACTB KD human THP1 macrophages
PRJNA1432734 | ENA
TranscriptomicsThe transcriptomic responses of THP1 human monocyte-like cells expressing SP110b to interferon gamma stimulation
SP110b is an interferon (IFN)-induced nuclear protein and may function as a transcriptional co-activator/repressor. IFNγ activates monocytes/macrophages thereby mediating inflammation. However, uncontrolled activation induces monocyte/macrophage cell death, which may cause immunopathology. We have d...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-58096 | biostudies-arrayexpress
TranscriptomicsThe sigma factor E of Mycobacterium tuberculosis modulates the inflammatory response of human THP1 cells
Mycobacterium tuberculosis (Mtb) is well adapted to survive in macrophages and usually subverts the bactericidal mechanisms of these professional phagocytes. The adaptation of Mtb to the intracellular life depends on its ability to regulate the expression of its genes. Among the most important bact...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-7870 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2
HMG-CoA reductase inhibitors, statins, have beneficial vascular effects beyond their cholesterol-lowering action. These pleiotropic effects include an anti-inflammatory effect on macrophages. Since macrophages play a central role in atherogenesis, we further characterized the effects on peripheral b...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4883 | biostudies-arrayexpress
TranscriptomicsFoam cell specific LXRM-NM-1 ligand
OBJECTIVE: The liver X receptor M-NM-1 (LXRM-NM-1) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. This makes it an interesting target for mechanistic study and treatment of atherosclerosis. METHODS AND RESULTS: We optimized a promising...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-39079 | biostudies-arrayexpress
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