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ProteomicsCrenigacestat inhibits osteogenic differentiation of human valve interstitial cells and seems promising for treatment of cardiovascular calcification
Vascular calcification is common pathology various forms of which presented in the half of humans. Calcific aortic valve disease (CAVD) is one of the most dangerous forms of vascular calcification. Despite high mortality there is no target therapy against CAVD. Thus, we tested crenigacestat (LY30394...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD029632 | Pride
Valve intersticial cells Timstof pro Vascular calcification Ly3039478 Notch inhibitors Crenigacestat Calcific aortic valve disease Shotgun proteomics 
TranscriptomicsGenome-wide transcript profiling for native porcine valvular interstitial cells and those cultured on TCPS and treated with TGF-β1
Fibrotic diseases have significant health impact and have been associated with differentiation of the resident fibroblasts into myofibroblasts. In particular, stiffened extracellular matrix and TGF-β1 in fibrotic lesions have been shown to promote pathogenic myofibroblast activation and progression ...
ORGANISM(S): Sus scrofa 
2013-09-02 | E-GEOD-48839 | biostudies-arrayexpress
ProteomicsProteomics analysis of physiological effect of ZBTB16 (PLZF) on osteogenic differentiation of human valve interstitial cells (VICs) by DDA PASEF on TimsToF Pro
During fundamental proteotranscriptomic analysis of human valve interstitial cells (VICs) osteogenic differentiation, we revealed ZBTB16 (PLZF) as one of the most upregulated proteins. Thus, to investigate its physiological role in VICs osteogenic differentiation we performed its overexpression by l...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD031572 | Pride
Zbtb16  plzf  osteogenic differentiation  valve interstitial cells  pasef  timstof pro 
UnknownMicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway.
Not available
S-EPMC5562804 | biostudies-literature
ProteomicsComparative analysis of DDA- and DIA-PASEF methods for proteomics analysis of human valve interstitial cells and osteoblasts during osteogenic differentiation
Shotgun proteomics is one of the key "omics" methods, the methodology of which is rapidly developing. Mass spectrometers of the TimsToF series (Bruker) with ion mobility are one of the young technological platforms for shotgun proteomics in which both data dependent (DDA) and data independent acquis...
ORGANISM(S): Homo sapiens (Human) 
2024-11-12 | PXD036566 | Pride
Data independent acquisition Pasef Shotgun proteomics Homo sapiens Timstof pro Calcific aortic valve disease 
ProteomicsLPA-TriCEPS crosslinked to human VICs
We used ligand-receptor capture mass spectrometry that identified major facilitator superfamily domain containing 5 (MFSD5) as a previously unreported Lp(a) receptor.
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD026861 | Pride
Mfsd5 Mass spectrometry Valve interstitial cells 
ProteomicsMitochondrial extracellular vesicles promote aortic valve calcification via carnitine O-octanoyltransferase
Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular morbidity and mortality with no effective medical therapy. We previously identified carnitine O-octanoyltransferase (CROT) as a mediator of mitochondrial dysfunction and vascular calcification. However, its role in CAVD remain...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-13 | PXD072508 | Pride
Mitochondrial extracellular vesicles Aortic valve calcification Mitochondria Valvular interstitial cells Lc-ms/ms 
ProteomicsSortilin Drives Valvular Interstitial Cells to a Combined Inflammatory Myofibroblast-Osteogenic Phenotype in Calcific Aortic Valve Disease as Revealed by Single-cell Analysis
Background: Calcific aortic valve disease (CAVD), the most common valve disease is comprised of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology of CAVD, and its role in the transformation of...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD038117 | Pride
Calcification Aortic stenosis Sortilin Inflammation Single-cell rna sequencing Fibrosis 
TranscriptomicsGene expression from healthy male and female porcine aortic valve leaflets
Calcific aortic valvular disease (CAVD) is characterized by sclerosis of the aortic valve leaflets and recent clinical studies have linked several other risk factors to this disease, including male sex. In this study we examined potential sex-related differences in gene expression profiles between ...
ORGANISM(S): Sus scrofa 
2013-01-02 | E-GEOD-33654 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in human valve interstitial cells of normal aortic valves and calcified aortic valves
Valve interstial cells(VICs) are the major cellular compents in the aortic valve. Under pathological circumstances, normal VICs differentiate into myofibroblasts or osteoblast-like phentotypes, which play important roles in the pathogenesis of calcified aortic valve disease. We used micrroarrary ana...
ORGANISM(S): Homo sapiens 
2016-10-23 | GSE88803 | GEO
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