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ProteomicsMolecular recognition of thyroglobulin by sortilin
Sortilin is a ubiquitous membrane receptor mediating protein trafficking along different cellular routes. In the thyroid gland, sortilin was proposed as a post-endocytic receptor of the thyroid hormone precursor, thyroglobulin (TG). It was reported that sortilin preferably shuttles iodinated TG to t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD062462 | Pride
Thyroid Sortilin Cryo-em Thyroglobulin Cross-linking mass spectrometry Crosslinking mass spectrometry Crosslinking ms Trafficking Xl-ms Iodination Endocytosis 
ProteomicsSortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays a key role in fatty acid oxidation; however, the regulatory mechanism of the subcellular...
ORGANISM(S): Mus Musculus 
2024-08-16 | PXD055014 |
ProteomicsSex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice
We evaluated the therapeutic potential of silencing sortilin expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce atherosclerosis and associated calcification. Male and female Ldl (low-density lipoprotein) receptor deficient mice were fed a high-fat diet and treated with ASO-Sort...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD048883 | Pride
Sortilin Mouse Sex Ldlr Aortic arch Atherosclerosis 
ProteomicsSortilin Drives Valvular Interstitial Cells to a Combined Inflammatory Myofibroblast-Osteogenic Phenotype in Calcific Aortic Valve Disease as Revealed by Single-cell Analysis
Background: Calcific aortic valve disease (CAVD), the most common valve disease is comprised of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology of CAVD, and its role in the transformation of...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD038117 | Pride
Calcification Aortic stenosis Sortilin Inflammation Single-cell rna sequencing Fibrosis 
ProteomicsSortilin-driven cancer secretome in HCC
To understand the secretome changes induced by sortilin in HCC cells.
ORGANISM(S): Homo sapiens (Human) 
2023-08-03 | PXD034886 | Pride
Human Sortilin Hcc Lc-ms/ms 
UnknownSortilin and hypertension.
Not available
S-EPMC9976622 | biostudies-literature
UnknownAn anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation.
Not available
S-EPMC11342335 | biostudies-literature
UnknownMolecular recognition of thyroglobulin by sortilin.
Not available
S-EPMC12936070 | biostudies-literature
TranscriptomicsDisrupted processing of long pre-mRNAs and widespread RNA missplicing are components of neuronal vulnerability from loss of nuclear TDP-43 (RNA-seq)
Cross-linking and immunoprecipitation coupled with high-throughput sequencing was used to identify binding sites within 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein which when mutated causes Amyotrophic Lateral Sclerosis (ALS). Use of massively parallel sequencing and spli...
ORGANISM(S): Mus musculus 
2011-03-03 | E-GEOD-27218 | biostudies-arrayexpress
UnknownSortilin as a Biomarker for Cardiovascular Disease Revisited.
Not available
S-EPMC8085299 | biostudies-literature
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