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ProteomicsCryo-EM structure of native human thyroglobulin
The Tthyroglobulin (Tg) protein is the essential fundament toto thyroid hormone synthesis, a key player playing a vital role in the regulation of metabolism, development and growth and serving as intraglandular iodine storage. Its structure is conserved among vertebrates. Tg is delivered through th...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029013 | Pride
Thyroglobulin Lc-ms Human 
ProteomicsStructure of Human Thyroglobulin
Thyroid hormones T3 and T4 play a crucial role in the regulation of vertebrate metabolism. The thyroglobulin (Tg) protein is key to thyroid hormone synthesis, and its structure is conserved among vertebrates. TgG is delivered through the secretory pathway to the lumen of the thyroid gland, where it ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD018452 | Pride
Human thyroglobulin Iodoniation Lc-ms Dda 
ProteomicsComparative Thyroglobulin Interactome Profiling
Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for T3 and T4 hormones. Many characterized Tg gene mutations produce secretion-defective variants resulting in congenital hypothyroidism (CH). Tg processing and secretion is controlled by extensive interactions with chaperone...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD019427 | Pride
Protein quality control Interactomics Thyroglobulin Congenital hypothyroidism Quantitative proteomics Ap-ms Proteostasis Protein folding 
ProteomicsThe structure of human thyroglobulin
Thyroglobulin protein is the precursor of thyroid hormones, which are essential for growth, development and control of metabolism in vertebrates. Hormone synthesis from thyroglobulin (TG) occurs in the thyroid gland via the iodination and subsequent coupling of pairs of tyrosine amino acids, whose p...
ORGANISM(S): Homo sapiens (Human) 
2020-02-06 | PXD014821 | Pride
Thyroxine  t3  t4  thyroid hormone  tyrosine iodination  cryo-em 
ProteomicsRevisiting iodination sites in thyroglobulin with an organ-oriented shotgun strategy
Identification of iodinated tyrosines in mouse thyroglobulin by a shotgun approach
ORGANISM(S): Mus musculus (Mouse) 
2011-05-05 | PRD000221 | Pride
ProteomicsMolecular recognition of thyroglobulin by sortilin
Sortilin is a ubiquitous membrane receptor mediating protein trafficking along different cellular routes. In the thyroid gland, sortilin was proposed as a post-endocytic receptor of the thyroid hormone precursor, thyroglobulin (TG). It was reported that sortilin preferably shuttles iodinated TG to t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD062462 | Pride
Thyroid Sortilin Cryo-em Thyroglobulin Cross-linking mass spectrometry Crosslinking mass spectrometry Crosslinking ms Trafficking Xl-ms Iodination Endocytosis 
ProteomicsCell survival and adaptation to chronic endoplasmic reticulum stress in thyrocytes
The large secretory glycoprotein, thyroglobulin, is the primary translation product of thyroid follicular cells. This difficult-to-fold protein is readily susceptible to structural alterations that render the misfolded thyroglobulin unable to be exported from the endoplasmic reticulum (ER) a known c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085006 | MassIVE
GenomicsThyroid dysplasia in C57BL/6NTac caused by a LINE-1 in Thyroglobulin
Thyroid dysplasia in C57BL/6NTac caused by a LINE-1 in Thyroglobulin
PRJNA1268983 | ENA
UnknownPhylogenetic analysis of the human thyroglobulin regions.
Not available
S-EPMC3464141 | biostudies-literature
UnknownStructural features of thyroglobulin linked to protein trafficking.
Not available
S-EPMC10578121 | biostudies-literature
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