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MetabolomicsThe Immune Response to Leads to Dichroism and Blue Pigmentation in Spotted Lanternfly Forewings
Coloration in creatures is a historical and longstanding scientific research hotspot for the profound significance of color. Normally, the blue color in nature is surprisingly scarce and produced by the micro- and nano-structures in most blue animals. Here, we report a dichromatic mechanism that the...
2024-09-04 | MTBLS8216 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
MetabolomicsNano-formulated bisphosphonate adjuvants simultaneously induce humoral and cellular immunity
Adjuvant is an important component of vaccines However, given the limitation of existing adjuvants in variety and mechanism, developing a unique and effective adjuvant is urgently needed for clinal applications. Recent studies have implicated that the mevalonate pathway plays an essential role in va...
2026-03-03 | MTBLS11696 | MetaboLights
ProteomicsHumoral Immune response of Galleria mellonella to BCG and APP
The humoral immune response of Galleria mellonella exposed to Mycobacterium bovis BCG (vaccine strain), 1x107 CFU (10 ul inoculum) were injected into the larvae. For low dose BCG challenge, 1x105 CFU (10 ul) were injected. For larval challenge with Actinobacillus pleuropneumoniae (APP), ~1.5x106 CFU...
ORGANISM(S): Galleria mellonella 
2021-09-08 | PXD015250 | Pride
Lc-ms/ms Galleria mellonella Proteomics Innate immune response Humoral Mycobacterium 
TranscriptomicsShcA is a Paracrine Integrator of the Adaptive Immune Response during Breast Cancer Progression
Using transgenic mouse models of breast cancer, we demonstrate that loss of ShcA signaling within mammary tumors results in extensive CD4+ T cell infiltration, activation and induction of a humoral immune response. Our studies reveal that ShcA signaling during early breast cancer progression is requ...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-18996 | biostudies-arrayexpress
TranscriptomicsTuberculosis Patients Blood Gene Expression Through Treatment (cured and end-of-treatment patients)
Background Accurate assessment of treatment efficacy would facilitate clinical trials of new anti-tuberculosis drugs. TB patients exhibit altered peripheral immunity which reverts during successful treatment. We hypothesised that these changes could be observed in whole blood transcriptome profiles...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-36238 | biostudies-arrayexpress
TranscriptomicsStore-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity
T follicular helper (TFH) cells promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory (TFR) cells limit GC reaction. Store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels mediated by STIM and ORAI proteins is a fundamental si...
ORGANISM(S): Mus musculus 
2016-03-10 | E-GEOD-79039 | biostudies-arrayexpress
ProteomicsLC-MS/MS EThcD of MERS-CoV and SARS-CoV S N-linked glycopeptides from recombinant spike ectodomains and whole MERS virions
Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus pandemic underscore the importance of finding ways to neutralize these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and ...
ORGANISM(S): Severe Acute Respiratory Syndrome-related Coronavirus (ncbitaxon:694009) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2020-03-13 | MSV000085097 | MassIVE
ModelsPalsson2013 - Fully-integrated immune response model (FIRM)
Palsson2013 - Fully-integration immune response model (FIRM) FIRM (The Fully-integrated Immune Response Modeling) is a hybrid construct incorporating multiple existing models of the immune system [De Boer et al., (1985);Bell, (1970); Marino and Kirschner, (2004) ]. FI...
2024-09-02 | BIOMD0000000608 | BioModels
ProteomicsProteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine
CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used for immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand the mechanisms behind the adaptiv...
ORGANISM(S): Homo Sapiens 
2022-03-09 | PXD032127 |
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