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TranscriptomicsShifting of immune responsiveness to house dust mite by influenza a infection genomic insights
House dust mite (HDM) extract (Greer Laboratories, Lenoir, NC) was resuspended in sterile phosphate-buffered saline (PBS) at a concentration of 0.5 mg (protein)/ml and 10 ul (5 ug dose) was administered to isofluorane-anesthetized mice intranasally. Groups of mice were infected either with influenza...
ORGANISM(S): Mus musculus 
2011-08-16 | E-MEXP-3325 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse BALBc strain mesenteric lymph nodes after response to common allergens.
In this study, MLN transcriptome profiling of female BALB/c mice was conducted in order to explore the molecular mechanism(s) of antigen sensitization using three of the most common food allergens; BLG, OVA and PNA. Analysis of cDNA microarray data revealed a complex network of genes that is modulat...
ORGANISM(S): Mus musculus 
2011-05-11 | E-MEXP-2676 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse spleen in response to egg ovomucoid treatment
Thirty female BALB/c mice of 6-8 weeks of age were purchased from Charles River (Montreal, QC, Canada) and divided randomly into control (n=15) and treated (n=15) groups. Mice were maintained on an egg free diet in the pathogen-free conditions at the University of Guelph Central Animal Facility. Ani...
ORGANISM(S): Mus musculus 
2010-07-15 | E-MEXP-2796 | biostudies-arrayexpress
TranscriptomicsThe effect of bisphenol A on human preadipocyte differentiation.
Background: Exposure to the endocrine-disrupting chemical bisphenol A (BPA) is correlated with obesity and promotes adipogenesis of human preadipocytes into mature adipocytes. However, the mechanism of action of BPA-induced human adipogenesis in vitro remains to be fully characterized. Methods: In t...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56085 | biostudies-arrayexpress
TranscriptomicsPulmonary retention of titanium dioxide nanoparticles and biological outcomes following low dose instillation in mice
Pulmonary exposure to high doses of nanoparticles (NP) leads to well characterized lung toxicity in addition to long-term NP retention. However, pulmonary NP accumulation and toxicity following low dose exposures are not well described. In the present study we sought to: (1) investigate particle ret...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-41041 | biostudies-arrayexpress
TranscriptomicsIntratracheally Instilled Titanium Dioxide Nanoparticles Translocate to Heart and liver and Activate Complement Cascade in the Heart of C57BL/6 Mice (Liver)
An estimated 1% or less of the nanoparticles (NPs) deposited in lungs translocate to systemic circulation and enter other organs; however this estimation may not be accurate considering the low sensitivity of the existing in vivo NP detection methods. Moreover, the biological outcomes of such low le...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56325 | biostudies-arrayexpress
TranscriptomicsIntratracheally Instilled Titanium Dioxide Nanoparticles Translocate to Heart and liver and Activate Complement Cascade in the Heart of C57BL/6 Mice (Heart)
An estimated 1% or less of the nanoparticles (NPs) deposited in lungs translocate to systemic circulation and enter other organs; however this estimation may not be accurate considering the low sensitivity of the existing in vivo NP detection methods. Moreover, the biological outcomes of such low le...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56324 | biostudies-arrayexpress
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