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TranscriptomicsRecapitulation of human premature aging by using iPSCs from Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature aging disease1-5, characterized by premature atherosclerosis and degeneration of vascular smooth muscle cells (SMCs)6-8. HGPS is caused by a single-point mutation in the LMNA gene, resulting in the generation of progerin...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-24487 | biostudies-arrayexpress
GenomicsCorrelated alterations in genome organization, histone methylation, and DNA-lamina interactions in Hutchinson-Gilford progeria syndrome
This SuperSeries is composed of the following subset Series: GSE41751: Correlated alterations in genome organization, histone methylation, and DNA-lamina interactions in Hutchinson-Gilford progeria syndrome (expression) GSE41757: Correlated alterations in genome organization, histone methylation, an...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-41764 | biostudies-arrayexpress
TranscriptomicsResistance of primary ovarian cancer cells to oncolytic adenoviruses part2 of 2
The mechanisms of primary ovarian cancer cells for resistance to viral oncolysis were investigated using Ad5/35.IR.E1A/TRAIL on clonal cultures derived from ovc316m cells. Part 2 of 2, 26 clonal ovc316m cultures additionally to Resistance of primary ovarian cancer cells to oncolytic adenoviruses par...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-15351 | biostudies-arrayexpress
TranscriptomicsResistance of primary ovarian cancer cells to oncolytic adenoviruses part1 of 2
The mechanisms of primary ovarian cancer cells for resistance to viral oncolysis were investigated using Ad5/35.IR.E1A/TRAIL on clonal cultures derived from ovc316m cells. Part 1 of 2, initital study involving 5 clonal ovc316m cultures Cells were infected for 8 days and cell survival determined by M...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15350 | biostudies-arrayexpress
TranscriptomicsS. fradiae WT and KOS155-3C R5/No Glucose 02/09/03
RNA timecourse data for Streptomyces fradiae wildtype (ATCC19609) and overproducing strain KOS155-3C(RUS). Strains were grown at 30 C in shake flask cultures in R5 medium with no glucose. RNA samples were harvested over 5 days as tylosin was produced. 12 h RNA samples of each strain were used as ...
ORGANISM(S): Streptomyces coelicolor 
2005-07-26 | E-GEOD-2995 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dormant and angiogenic breast cancer, osteosarcoma, liposarcoma and brain tumor cell lines
The Goal of this study is to explore the transcriptional differences between angiogenic and non-angiogenic tumors generated in Dr. Folkman's Lab, Harvard Medical School.
Referneces:
Almog N, Henke V, Flores L, Hlatky L, Kung AL, Wright RD, Berger R, Hutchinson L, Naumov GN, Bender E, Akslen LA...
ORGANISM(S): Homo sapiens 
2009-02-03 | E-TABM-390 | biostudies-arrayexpress
ProteomicsAn in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer
Small cell lung cancer (SCLC) is characterized by exquisite chemosensitivity followed by rapid emergence of chemoresistance. To identify genetic events that drive resistance to cisplatin-etoposide chemotherapy, we conducted cDNA overexpression and CRISPR knockout screens in an in vivo platform cente...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-20 | PXD048813 | Pride
Crispr knockout Global phosphoproteome Small cell lung cancer Imac Tmt Pdx 
UnknownCalcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative.
Not available
S-EPMC3046029 | biostudies-literature
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
GenomicsBRD4 binding sites in transformed fibroblasts
Analysis of BRD4 ChIP-seq data of two types of human transformed fibroblasts (WT and HGPS) to identify specific and common binding sites for BRD4. Transformed cell lines were obtained by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S) of primary skin fibrobl...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-61325 | biostudies-arrayexpress
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