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UnknownModels to Predict Hepatitis B Virus Infection Among Patients With Cancer Undergoing Systemic Anticancer Therapy: A Prospective Cohort Study.
Not available
S-EPMC7351320 | biostudies-literature
ProteomicsUnbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in SCLC
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, inhibits SCLC expansion in culture and in vivo. Conversely, GNAS (G-protein ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-17 | PXD018209 | Pride
Inhibitor beads Analog specific Kinase proteomics Small cell lung cancer 
ProteomicsOncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism
Genetic alterations that activate protein kinase A (PKA) signaling are found across many tumor types, but their downstream oncogenic mechanisms are poorly understood. We used global phosphoproteomics and kinome activity profiling to map the conserved signaling outputs driven by diverse genetic chang...
ORGANISM(S): Homo sapiens (Human) 
2023-02-09 | PXD025508 | Pride
Aurka Fibrolamellar carcinoma Pim2 Pka Myc Liver cancer 
UnknownCyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells.
Not available
S-EPMC5055750 | biostudies-literature
UnknownIntegrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation.
Not available
S-EPMC1088016 | biostudies-literature
UnknownDesigning angle-independent structural colors using Monte Carlo simulations of multiple scattering.
Not available
S-EPMC7848739 | biostudies-literature
TranscriptomicsAnalysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN
Alginate overproduction by P. aeruginosa, also known as mucoidy is associated with chronic endobronchial infections in cystic fibrosis (CF). Alginate biosynthesis in this bacterium is initiated by the extracytoplasmic function sigma factor (σ22, AlgU/T). In the wild type (wt) nonmucoid strains, su...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-03-01 | E-GEOD-35248 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression profile in skin of Hoxc13 gene-targeted mice
Hoxc13 has been shown to be essential for proper hair shaft differentiation as Hoxc13 gene-targeted (Hoxc13tm1Mrc) mice completely lack external hair. Because of the phenotypic parallels to the Foxn1nu (nude) mutant mice, we tested whether Hoxc13 and Foxn1 act in a common pathway of hair follicle (H...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-23759 | biostudies-arrayexpress
UnknownIndividualizing NSAID therapy in axial spondyloarthritis: N-of-1 trials with Bayesian analysis.
Not available
S-EPMC12671866 | biostudies-literature
UnknownSARS-CoV-2 infection drives local inflammation of the intestinal epithelium in immunocompromised patients with cancer.
Not available
S-EPMC12496208 | biostudies-literature
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