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UnknownHighly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development.
Durability of T follicular helper (Tfh) cell responses is pivotal for generating high affinity antibodies. We characterized Tfh cell responses to HIV Env immunization longitudinally in non-human primates, analyzing >500,000 CD4+ T cells from 192 lymph node (LN) samples collected over 60 w...
S-EPMC12782651 | biostudies-literature
Unknown<i>APOL1</i> Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.

Background

APOL1 renal risk variants are strongly associated with chronic kidney disease in Black adults, but reported associations with cardiovascular disease (CVD) have been conflicting.

Methods

We examined associations of APOL1 with incident coronary heart disease (n=...
S-EPMC6339526 | biostudies-literature
UnknownA Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage.

Background

Intracerebral hemorrhage (ICH) has an estimated heritability of 29%. We developed a genomic risk score for ICH and determined its predictive power in comparison to standard clinical risk factors.

Methods

We combined genome-wide association data from individuals of European ...
S-EPMC10050100 | biostudies-literature
UnknownGenome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.

Background and purpose

Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans.

Methods

The COMPASS (Consortium of Minority Population...
S-EPMC7387190 | biostudies-literature
UnknownSerum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Objective

To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.

Methods

Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphism...
S-EPMC6404465 | biostudies-literature
UnknownMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found ...
S-EPMC5968830 | biostudies-literature
UnknownGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individu...
S-EPMC6277418 | biostudies-literature
UnknownStroke genetics informs drug discovery and risk prediction across ancestries.
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-Eu...
S-EPMC9524349 | biostudies-literature
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