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TranscriptomicsScreening for chromosomal aberrations by array CGH in 74 patients with congenital hypothyroidism
Congenital Hypothyroidism occurs in 1:3500 live births and is therefore the most common congenital endocrine disorder. A spectrum of defective thyroid morphology, termed thyroid dysgenesis, represents 80% of permanent CH cases. Although several candidate genes have been implicated in thyroid develop...
ORGANISM(S): Homo sapiens 
2010-05-31 | E-GEOD-18152 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebella from pups exposed to PTU to induce hypothyroidism
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. Cerebella were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected...
ORGANISM(S): Mus musculus 
2008-05-02 | E-MEXP-1048 | biostudies-arrayexpress
TranscriptomicsCongenital hypothryrodism and male rat liver: control vs congenital hypothryoidism
Transcriptional profiling of rat liver comparing male rats with congenital hypothyrodism (CH) vs intact at adulhood. Here we studied how CH influences liver gene expression program in adulthood. Thyroid hormones are required for normal growth and development in mammals. Congenital-neonatal hypothyro...
ORGANISM(S): Rattus norvegicus 
2012-03-10 | E-GEOD-32705 | biostudies-arrayexpress
GenomicsMicrobial Features in Pregnant Women with Hypothyroidism
Microbial Features in Pregnant Women with Hypothyroidism
PRJEB38373 | ENA
ProteomicsLiver proteomics investigations into hypothyroidism treated with Atractylodis Macrocephalae Rhizome
Hypothyroidism model rats were established with PTU (10 mg•kg-1•d-1) and treated with Atractylodis Macrocephalae Rhizome and its fractions (volatile oil fraction, lactones fraction, atractyloside fraction, oligosaccharide fraction, and crude polysaccharide fraction) for 20 d. The experiment (having ...
ORGANISM(S): Rattus Rattus 
2021-03-04 | PXD024535 |
TranscriptomicsComparison of gene expression in thyrocytes between wildtype and thyroid-specific IFNg transgenic mice
Hürthle cells are found in thyroid tumors and autoimmunity, and have a unique appearance characterized by swollen eosinophilic cytoplasm filled with mitochondria and hyperchromatic nucleus. The pathogenesis of Hürthle cells remains unknown. We have generated transgenic mice expressing IFNg specifica...
ORGANISM(S): Mus musculus 
2009-07-01 | E-GEOD-15114 | biostudies-arrayexpress
ProteomicsProteomics of hypothyroidism during pregnancy
proteomics of hypothyroidism during first half of pregnancy (32 samples)
ORGANISM(S): Homo Sapiens 
2024-12-18 | PXD058969 |
ProteomicsHypothyroidism symptoms in LT4-euthyroid thyroidectomized patients reflect an alteration of the serum proteome
In patients undergoing thyroidectomy one of the goals of post-surgical follow-up is the correct maintenance of thyroid hormone (TH) levels by replacement therapy with levo-thyroxine (LT4). Nevertheless, some patients complain of symptoms of hypothyroidism (memory loss, weight gain, fatigue, depressi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028378 | Pride
Quality of life Lt4 Hypothyroidism Proteomics Reduced ft3 
Proteomicsplasma proteomic characteristics of hypothyroidism in the first half of pregnancy
This projects contains results of plasma proteomic characterisitics of hypothyroidism in the first half of pregnancy.
ORGANISM(S): Homo Sapiens 
PXD054850 |
GenomicsBrain hypothyroidism leads to immune tolerance in microglia in Alzheimer's disease [RNA-seq]
Brain hypothyroidism leads to immune tolerance in microglia in Alzheimer's disease [RNA-seq]
PRJNA907147 | ENA
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