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MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
TranscriptomicsTranscriptional Response of Adult Mouse Brain to Hypoxia
Since normal brain function depends upon continuous oxygen delivery and short periods of hypoxia can precondition against subsequent ischemia, this study examined the effects of brief hypoxia on the whole genome transcriptional response in adult mouse brain. Genomic expression profiling was perfrome...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-19709 | biostudies-arrayexpress
TranscriptomicsFunctional genomics in perinatal asphyxia and fetal asphyctic preconditioning in the brain
Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. G...
ORGANISM(S): Rattus norvegicus 
2014-12-22 | E-GEOD-42676 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection
Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data sugges...
ORGANISM(S): Mus musculus 
2009-01-17 | E-GEOD-14366 | biostudies-arrayexpress
ProteomicsThe plasma DIA proteomic analysis for humans aimming at exploring the mechanism of RIPC’s protective effect under hypobaric hypoxia condition.
The plasma proteome profiling data come from the humans who received remote ischemic preconditioning treatment and experienced hypobaric hypoxia exposure then.
ORGANISM(S): Homo Sapiens 
2022-01-25 | PXD031247 |
ProteomicsMechanism of recovery following human stem cell-derived extracellular vesicle treatment to cerebral ischemia
Characterization of hMSC cell and EV revealed that hypoxia preconditioning upregulated 41 expression of metabolic proteins related to HIF signaling, neurogenesis and EV biogenesis.
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD041677 | Pride
Human mesenchymal stem cells  extracellular vesicles  hypoxia  ischemia 
ProteomicsMouse kidney cisplatin TAILS - The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury
Profiling of proteolytic events mouse kidneys during cisplatin-induced kidney damage. Kidneys from vehicle-treated mice are compared to cisplatin-treated mice and cisplatin treatment in animals preconditioned by hypoxia or calory restriction regimes.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-29 | PXD007186 | Pride
Mouse  kidney 
UnknownHypoxia preconditioning protection of corneal stromal cells requires HIF1alpha but not VEGF.
Not available
S-EPMC2684561 | biostudies-literature
UnknownPEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury.
Not available
S-EPMC8834864 | biostudies-literature
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