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ProteomicsExtended proteomes of brain organ from individual neonatal rats for understanding hypoxia–ischemia-related brain Injury and drug action.
Next-generation shotgun proteomics of brain organ from individual neonatal rats suffering hypoxia-ischemia related brain injury in order to assess their response to a novel pharmaceutical drug.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-13 | PXD050059 | Pride
Drug Injury Brain Ischemia Proteomics Encephalopathy Molecular pathways Hypoxia 
GenomicsAge dependent effects of hypoxia-ischemia in neonatal mice brain
Age dependent effects of hypoxia-ischemia in neonatal mice brain
PRJNA603699 | ENA
TranscriptomicsGene expression changes in the periventricular white matter of neonatal piglets at a defined 48h time point following a hypoxic-ischemic insult: a comparison of piglets left untreated and those treated with a remote post-conditioning stimulus applied to the hind leg immediately after the insult.
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. 16 Large White newborn female piglets were exposed to a tightl...
ORGANISM(S): Sus scrofa 
2016-09-21 | E-MTAB-5125 | biostudies-arrayexpress
ProteomicsArg1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
Ischemic/hypoxic injury significantly damages vascular function, detrimentally im-pact-ing patient outcomes. Changes in mitochondrial structure and function are closely associated with ischemia/hypoxia-induced vascular dysfunction. The mecha-nism of this process remains elusive. Using rat models of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-02 | PXD063156 | Pride
Mtdna Ischemic/hypoxic injury Mitochondria Vascular dysfunction Arg1 
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
TranscriptomicsTranscription profiling of rat NRVMs response to ischemia and reperfusion events using Coverslip Hypoxia
NRVMs were subjected to varying durations of ischemia or ischemia+reperfusion using coverslip hypoxia. Expression profiling was used to identify genes that are differentially regulated in either event. We used microarrays to detail the global program of gene expression underlying ischemia and reper...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6701 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced miR-210 modulates gene expression in response to acute peripheral ischemia.
Peripheral Artery Disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to acute and chronic ischemia is urgently needed to improve therapeutic options. The aim of this study is understanding miR...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-43340 | biostudies-arrayexpress
TranscriptomicsExpression data from ischemia and reperfusion events in NRVMs using Coverslip Hypoxia
NRVMs were subjected to varying durations of ischemia or ischemia+reperfusion using coverslip hypoxia. Expression profiling was used to identify genes that are differentially regulated in either event. We used microarrays to detail the global program of gene expression underlying ischemia and reperf...
ORGANISM(S): Rattus norvegicus 
2007-01-11 | GSE6701 | GEO
ProteomicsSildenafil Combined with Controlled Hypothermia Mitigates Microglial Activation After Neonatal Hypoxia-Ischemia in Rat.
The only validated treatment to prevent brain damage associated with hypoxia-ischemia (HI) encephalopathy of the newborn is controlled hypothermia with limited benefits. Additional putative neuroprotective drug candidates include sildenafil citrate, a phosphodiesterase-type 5 inhibitor. The main obj...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-30 | PXD045168 | Pride
Label free Hypoxia-ischemia Dia Microglia 
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