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ProteomicsFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C, mediates ER-phagy. While FAM134B mutations ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-24 | PXD050983 | Pride
Fam134a Fam134b Fam134c Endoplasmic reticulum Axon 
ProteomicsDelivery of MFF through mitochondria-derived vesicles regulates melanosome maturation
Melanosomes are lysosome-associated organelles that produce and accumulate melanin. Their biogenesis begins with the trafficking of melanogenic proteins from the endo-lysosomal system into non-pigmented vacuoles derived from endosomes. Subsequently, melanosome maturation proceeds with the export and...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD051372 | Pride
Mitochondria Mff Melanosome 
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