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ProteomicsIdentification of a Stable Stool Peptidomic Signature for Monitoring IBD Activity
Introduction Monitoring disease activity in inflammatory bowel disease (IBD) is essential for guiding therapy and preventing irreversible tissue damage. Colonoscopy, although the gold standard, is invasive and unsuitable for frequent monitoring, while fecal calprotectin lacks accuracy within its dia...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074117 | Pride
Human Peptidomics Machine learning Inflammatory bowel disease Biomarker discovery Proteomics Stool Clinical mass spectrometry Nested cross validation Ibd activity 
ProteomicsLow mass blood peptides discriminative of IBD severity
The enriched low mass proteome is unexplored as a source of differentiators for diagnosing and monitoring Inflammatory Bowel Disease (IBD) activity, less invasively than colonoscopy and histopathology. Differences in the enriched low mass plasma proteome (<25kDa) were assessed by label-free quantita...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD002821 | Pride
Biomarker Ibd Mrm Spp24 Proteomic Guc2a 
TranscriptomicsColon gene expression signatures in mice mono-associated with IBD-associated micro-organisms
Studying host-microbiota interactions is fundamental to understand mechanisms involved in intestinal inflammation and inflammatory bowel diseases. In this work, we studied these interactions in mice mono-associated with 4 bacteria and 2 yeasts, all representative of intestinal microbiota and/or asso...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-63299 | biostudies-arrayexpress
TranscriptomicsPredicting response to vedolizumab therapy using mucosal transcriptomics in IBD patients
In this study we wanted to identify baseline predictors of successful vedolizumab therapy in patients with inflammatory bowel disease.
ORGANISM(S): Homo sapiens 
2019-08-23 | E-MTAB-7845 | biostudies-arrayexpress
TranscriptomicsThe immunoregulatory effect of macrophage-specific PPAR gamma deficiency on experimental inflammatory bowel disease
Inflammatory bowel disease (IBD) is a condition characterized by severe intestinal inflammation and immune cell activation. The severity of the disease can be mitigated by compounds which activate peroxisome proliferator-activated receptor gamma (PPAR gamma), a receptor present widely in tissues in...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-23421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ileum and colonic tissues from patients with Crohns disease or ulcerative colitis
Samples for microarray analysis were derived from terminal ileum and colonic tissues from probands with Crohn's disease and Ulcerative Colitis and control patients, respectively. IBD tissue biopsies from non-inflamed regions 10 cm distant from pathological areas were selected. To minimize inter-indi...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1152 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in IBD rat treat with MSC transplantation
Investigation of whole genome gene expression level changes in Inflammatory bowel disease rats after MSC transplantation, compared to IBD control rats, and to explore the mechanism of MSC transplantation. A four chip study using total RNA recovered from two separate IBD rats after MSC transplantatio...
ORGANISM(S): Rattus norvegicus 
2015-05-08 | E-GEOD-68653 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of colonic mucosa biopsies in patients with inflammatory bowel disease
Microarrays were used to analyze the gene expression in endoscopic-derived intestinal mucosal biopsies from patients with inflammatory bowel disease (IBD) and controls Mucosal biopsies were obtained at endoscopy from the colon of 97 ulcerative colitis (UC), 8 Crohn's disease (CD) patients and 11 co...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-59071 | biostudies-arrayexpress
UnknownClinical Trials [and Tribulations]: The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK.
Not available
S-EPMC7337665 | biostudies-literature
GenomicsIRON-IBD
Effects of different iron replacement methods to gut microbiome of IBD and non IBD patients
PRJEB48168 | ENA
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