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ProteomicsParallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
G-quadruplexes (G4s) are four-stranded nucleic acid structures abundant at gene promoters. They can adopt several distinctive conformations. G4s have been shown to form in the herpes simplex virus-1 (HSV-1) genome during its viral cycle. Here by cross-linking/pull-down assay we identified ICP4, the ...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-09-10 | PXD024743 | Pride
Proteins G-quadruplex Hsv-1 Icp4 
GenomicsTranscriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cells
Transcriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cells
PRJNA1368599 | ENA
TranscriptomicsTranscriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cells
Successful viral infections reflect the balanced outcome of a tightly regulated program of viral gene expression and manipulation of the host cell to favor production of new infectious particles. The productive replication cycle of herpes simplex virus 1 (HSV-1) is dependent on the immediate-early e...
ORGANISM(S): Homo sapiens 
2026-03-13 | GSE311056 | GEO
GenomicsGenome-wide analysis of RNA polymerase II occupancy during HSV-1 infection in the presence and absence of ICP4.
The goal of this study was to identify how the occupancy of RNA polymerase II (Pol II) on the host genome changes during HSV-1 infection and is impacted by the viral immediate early protein ICP4. Pol II ChIP-seq experiments after infection with the wild-type (WT) virus and mutant ICP4 (n12) virus, c...
ORGANISM(S): Homo sapiens 
2021-07-07 | GSE171600 | GEO
UnknownThe HSV-1 ICP4 Transcriptional Auto-Repression Circuit Functions as a Transcriptional "Accelerator" Circuit.
Not available
S-EPMC7326776 | biostudies-literature
UnknownICP0 antagonizes ICP4-dependent silencing of the herpes simplex virus ICP0 gene.
Not available
S-EPMC2809113 | biostudies-literature
UnknownThe herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
Not available
S-EPMC5737704 | biostudies-literature
GenomicsTranscriptomic analysis of early HSV-1 transcription in the absence of the immediate early protein, ICP4 [PROCap]
Transcriptomic analysis of early HSV-1 transcription in the absence of the immediate early protein, ICP4 [PROCap]
PRJNA985585 | ENA
GenomicsTranscriptomic analysis of early HSV-1 transcription in the absence of the immediate early protein, ICP4 [Nanopore]
Transcriptomic analysis of early HSV-1 transcription in the absence of the immediate early protein, ICP4 [Nanopore]
PRJNA987739 | ENA
GenomicsTranscriptomic analysis of early HSV-1 transcription in the absence of the immediate early protein, ICP4 [PROSeq]
Transcriptomic analysis of early HSV-1 transcription in the absence of the immediate early protein, ICP4 [PROSeq]
PRJNA985587 | ENA
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