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UnknownStructure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
Not available
S-EPMC5473211 | biostudies-literature
ProteomicsA single-amino-acid cleavage controls mitochondrial complexome stability
Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins, and defects in this maturation step are implicated in severe human diseases, yet the functional impact in humans remain unclear. We show that the intermediate cleaving peptidase ICP55, that removes a ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD068519 | Pride
Complexome N-terminome Icp55 Proteomics Co-fractionation Mass spectrometry 
ProteomicsN-terminome data for "A single-amino-acid cleavage controls global mitochondrial complex integrity"
Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins, and defects in this maturation step are implicated in severe human diseases, yet the functional impact in humans remain unclear. This HUNTER N-terminome dataset identify over one hundred human ICP55 s...
ORGANISM(S): Homo sapiens (Human) 
2026-07-22 | PXD070326 | Pride
A single-amino-acid cleavage controls global mitochondrial complex integrity 
ProteomicsProteomics data for "A single-amino-acid cleavage controls global mitochondrial complex integrity"
Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins, and defects in this maturation step are implicated in severe human diseases, yet the functional impact in humans remain unclear. This dataset analysis quantiative changes in the proteome of mitochondr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-01 | PXD070247 | Pride
N-terminome Mitochondria Protein complex stability Respiratory chain Proteomics 
UnknownIdentification of cleavage sites and substrate proteins for two mitochondrial intermediate peptidases in Arabidopsis thaliana.
Not available
S-EPMC4986872 | biostudies-literature
UnknownMitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae.
Not available
S-EPMC3792884 | biostudies-literature
ProteomicsChaFRADIC: A novel SCX-based approach for N-terminal Enrichment
Step 1: Cell lysis of yeast sphaeroblast (Saccharomyces cerevisiae) and carbamidomethylation. Step 2: Isotopic labeling with dimethylation (light + medium). Step 3: Proteolytic digestion with trypsin (ArgC specificity because of blocked lysines by dimethylation). Step 4: Enrichment via ChaFRADIC...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2013-08-09 | PXD000292 | Pride
Chafradic Yeast Protease Peptidase Icp55 Cofradic N-terminal Degradomics 
UnknownComparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast.
Not available
S-EPMC5383775 | biostudies-literature
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