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ProteomicsContribution of IFIX to nuclear and cytoplasmic proteome changes during immune signaling
IFIX is a nuclear DNA sensor that is known to induce cytokine expression in response to both cytoplasmic DNA and foreign DNA in the nucleus. Here, we examine the concomitant nuclear and cytoplasmic proteome changes that are driven by IFIX during immune response to viral infection and transfection of...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2021-06-02 | PXD025101 | Pride
Nuclear dna sensor Ptm Innate immunity Ifix 
ProteomicsThe antiviral protein IFIX is targeted for degradation during HSV-1 infection
IFIX has been shown to be an antiviral factor druing HSV-1 infection. Here we define a mechanism by which IFIX exerts it antiviral function and discover a means by which the virus target IFIX to inhibit this function.
ORGANISM(S): Homo sapiens (Human) 
2017-01-16 | PXD005152 | Pride
Hsv-1 Ifix 
Proteomics,MultiomicsInteractome analysis of PYHIN immune regulators
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By design...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079955 | MassIVE
OtherThe functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
Data from ProteomeXchange, PXD ID: PXD001572. File: 2012_07_03_IFIXGFP_PD13.mzml. Published as part of . From the Abstract: {{i}} he human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein intera...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310018443 | GPMDB
Resource Reanalysis 
UnknownInterferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma.
Not available
S-EPMC8486792 | biostudies-literature
UnknownThe functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
Not available
S-EPMC4358659 | biostudies-literature
UnknownNKD2 as a Mediator of IFIX Antioncogene-Induced Wnt Signalling and Epithelial-Mesenchymal Transition in Human OSCC.
Not available
S-EPMC11745820 | biostudies-literature
UnknownHuman Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.
Not available
S-EPMC5393386 | biostudies-literature
UnknownThe DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle.
Not available
S-EPMC8269231 | biostudies-literature
ProteomicsInteractome analysis of PYHIN immune regulators
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By design...
ORGANISM(S): Homo sapiens (Human) 
2015-03-12 | PXD001572 | Pride
Protein interactions Ifix Dna sensing 
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