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ProteomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-rich and...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD044048 | Pride
Smubp-2 Thoc Ighmbp2 Smard1 Mrna homeostasis Rna helicase 
ProteomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 (DSMA1) associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD043336 | Pride
Thoc Mrna-homeostasis Ighmbp2 Smard1 Rna helicase 
GenomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
PRJNA994913 | ENA
GenomicsIGHMBP2 deletion suppresses translation and activates the integrated stress response [Ribo-Seq]
IGHMBP2 deletion suppresses translation and activates the integrated stress response [Ribo-Seq]
PRJNA1046391 | ENA
GenomicsIGHMBP2 deletion suppresses translation and activates the integrated stress response [RNA-Seq]
IGHMBP2 deletion suppresses translation and activates the integrated stress response [RNA-Seq]
PRJNA1046396 | ENA
UnknownThe contribution and therapeutic implications of IGHMBP2 mutations on IGHMBP2 biochemical activity and ABT1 association.
Not available
S-EPMC10999323 | biostudies-literature
TranscriptomicsIGHMBP2 deletion suppresses translation and activates the integrated stress response [RNA-Seq]
IGHMBP2 is a non-essential, superfamily 1 DNA/RNA helicase with incompletely understood biological function. Mutagenesis in IGHMBP2 is found in patients with rare neuromuscular diseases SMARD1 and CMT2S. IGHMBP2 is implicated in translational and transcriptional regulation via biochemical associatio...
ORGANISM(S): Homo sapiens 
2023-12-19 | GSE248889 | GEO
OtherIGHMBP2 deletion suppresses translation and activates the integrated stress response [Ribo-Seq]
IGHMBP2 is a non-essential, superfamily 1 DNA/RNA helicase with incompletely understood biological function. Mutagenesis in IGHMBP2 is found in patients with rare neuromuscular diseases SMARD1 and CMT2S. IGHMBP2 is implicated in translational and transcriptional regulation via biochemical associatio...
ORGANISM(S): Homo sapiens 
2023-12-19 | GSE248888 | GEO
TranscriptomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 (DSMA1) associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-...
ORGANISM(S): Homo sapiens 
2024-01-18 | GSE237412 | GEO
UnknownIGHMBP2 deletion suppresses translation and activates the integrated stress response.
Not available
S-EPMC10760061 | biostudies-literature
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