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ProteomicsCLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
This study demonstrated that circadian gene clock plays an important role in the regulation of mitochondrial homeostasis. In this process, CLOCK interacts with PUF60 and affects the mRNA stability of Drp1.
ORGANISM(S): Mus Musculus 
PXD032057 |
ProteomicsN6-methyl adenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
RNA modifications are integral to regulation of RNA metabolism. One such abundant mRNA modification is m6A, which impacts various aspects of RNA metabolism including splicing, transport and degradation. Current knowledge about proteins recruited to m6A to carry out these molecular processes is still...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-22 | PXD006498 | Pride
Interaction proteomics Fmr1 M6a G3bp1 Mrna homeostasis 
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
PXD021722 |
ProteomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 (DSMA1) associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD043336 | Pride
Thoc Mrna-homeostasis Ighmbp2 Smard1 Rna helicase 
ProteomicsRat liver treated by PCN
The combination analyses of transcriptomics, proteomics, phosphoproteomics, and metabolomics in rat liver after repeated oral doses of PXR agonist, PCN, for 7 days were conducted to understand the roles for PXR on non-genotoxic signaling and energy homeostasis. mRNA and proteins in homogenate supern...
ORGANISM(S): Rattus Rattus (black Rat) 
2018-01-01 | PXD006305 | JPOST Repository
ProteomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-rich and...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD044048 | Pride
Smubp-2 Thoc Ighmbp2 Smard1 Mrna homeostasis Rna helicase 
GenomicsStabilization of insulin receptor mRNA by Star-PAP in metabolic homeostasis
Stabilization of insulin receptor mRNA by Star-PAP in metabolic homeostasis
PRJNA1520303 | ENA
GenomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
PRJNA994913 | ENA
GenomicsStabilization of insulin receptor mRNA by Star-PAP in metabolic homeostasis [ATAC-seq]
Stabilization of insulin receptor mRNA by Star-PAP in metabolic homeostasis [ATAC-seq]
PRJNA1521294 | ENA
GenomicsMitochondrial Ca2+ homeostasis controls inter-compartmental proteostasis in Arabidopsis plants [mRNA]
Mitochondrial Ca2+ homeostasis controls inter-compartmental proteostasis in Arabidopsis plants [mRNA]
PRJNA773762 | ENA
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