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ProteomicsControl and Ikbkap-knockout MEFs LC-MSMS
Mouse Ikbkap gene encodes IKAP/Elp1- one of the core subunits of Elongator- and has been implicated in translational regulation. However, a role for IKAP in genome maintenance remains unclear. In this study, we analyze proteins from control and Ikbkap depletion mouse embryonic fibroblasts (MEF) usin...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD024628 | Pride
Lc-msms Mefs Ikbkap 
TranscriptomicsExpression data from P15 mouse testes control and Ikbkap-knockout mice
Ikbkap/Elp1 regulates genes involved in spermatogenesis. Ikbkap deficiency causes male infertility by disrupting meiotic progression. In this dataset, we include the expression data for control and Ikbkap-knockout mouse testis. We analyzed the gene expression in control and Ikbkap-knockout testes us...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-42230 | biostudies-arrayexpress
TranscriptomicsExpression data from P15 mouse testes control and Ikbkap-knockout mice
Ikbkap/Elp1 regulates genes involved in spermatogenesis. Ikbkap deficiency causes male infertility by disrupting meiotic progression. In this dataset, we include the expression data for control and Ikbkap-knockout mouse testis.
ORGANISM(S): Mus musculus 
2013-12-31 | GSE42230 | GEO
UnknownLoss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.
Not available
S-EPMC2630687 | biostudies-literature
Proteomics,MultiomicsAnalysis of peripheral neuron protein expression in the absence of Ikbkap/Elp1
Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1, a gene encoding the scaffolding protein for the Elongator complex. This highly conserved complex is required for the methoxy-carbonyl-methyl (mcm5) modification of uridines located in the wobble position of tRNA molecules (U34). In F...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000081568 | MassIVE
UnknownA humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect.
Not available
S-EPMC1976430 | biostudies-literature
UnknownFamilial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons.
Not available
S-EPMC3831979 | biostudies-literature
UnknownAntisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice.
Not available
S-EPMC6007753 | biostudies-literature
UnknownBlocking of an intronic splicing silencer completely rescues IKBKAP exon 20 splicing in familial dysautonomia patient cells.
Not available
S-EPMC6125618 | biostudies-literature
UnknownAssociation between IKBKAP polymorphisms and Hirschsprung's disease susceptibility in Chinese children.
Not available
S-EPMC9253937 | biostudies-literature
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