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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
MetabolomicsMucosal-Associated-Invariant-T (MAIT) cells stimulated with IL-12/IL-12, anti-CD3/CD28 or both for 16 hours
Not available
ORGANISM(S): Homo sapiens 
ST001653 | MetabolomicsWorkbench
GenomicsA novel t(5 7)(q31 q21/CDK6::IL3 in immature T-cell acute lymphoblastic leukemia with IL3 overexpression and reactive eosinophilia [WTE]
A novel t(5 7)(q31 q21/CDK6::IL3 in immature T-cell acute lymphoblastic leukemia with IL3 overexpression and reactive eosinophilia [WTE]
PRJNA870485 | ENA
GenomicsA novel t(5 7)(q31 q21/CDK6::IL3 in immature T-cell acute lymphoblastic leukemia with IL3 overexpression and reactive eosinophilia [SNP]
A novel t(5 7)(q31 q21/CDK6::IL3 in immature T-cell acute lymphoblastic leukemia with IL3 overexpression and reactive eosinophilia [SNP]
PRJNA869310 | ENA
ProteomicsHuman cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
Adeno-associated viruses (AAVs) are foundational gene delivery tools for basic science and clinical therapeutics. However, lack of mechanistic insight, especially for engineered vectors created by directed evolution, can hamper their application. Here, we adapted an unbiased human cell microarray pl...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD045380 | Pride
Interleukin-3 Aav9 Il3 
UnknownIL3-Driven T Cell-Basophil Crosstalk Enhances Antitumor Immunity.
Not available
S-EPMC11219266 | biostudies-literature
TranscriptomicsA novel t(5;7)(q31;q21/CDK6::IL3 in immature T-cell acute lymphoblastic leukemia with IL3 overexpression and reactive eosinophilia [WTE]
IL3 expression and reactive eosinophils
ORGANISM(S): Homo sapiens 
2025-08-11 | GSE211476 | GEO
GenomicsA novel t(5;7)(q31;q21/CDK6::IL3 in immature T-cell acute lymphoblastic leukemia with IL3 overexpression and reactive eosinophilia [SNP]
IL3 expression and reactive eosinophils
ORGANISM(S): Homo sapiens 
2025-08-11 | GSE211170 | GEO
MetabolomicsMetabolomic analysis of riboswitch containing E. coli recombinant expression system
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells. This metabolic burden analysis was performed against a number of recombinant expression systems and co...
2017-11-16 | MTBLS393 | MetaboLights
UnknownIL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings.
Not available
S-EPMC9655151 | biostudies-literature
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