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MetabolomicsCaridac untargeted lipidomics in Sham or TAC-operated mice pretreated with AAV9-NC or AAV9-cTnT-shSlc9a3

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13701 | MetaboLights
ProteomicsHuman cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
Adeno-associated viruses (AAVs) are foundational gene delivery tools for basic science and clinical therapeutics. However, lack of mechanistic insight, especially for engineered vectors created by directed evolution, can hamper their application. Here, we adapted an unbiased human cell microarray pl...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD045380 | Pride
Interleukin-3 Aav9 Il3 
GenomicsAdeno-associated virus strain:AAV8/AAV9
Adeno-associated virus strain:AAV8/AAV9 Raw sequence reads
PRJNA1108715 | ENA
ProteomicsBVES-HA IP-mass from AAV9-BVES-HA injected mouse skeletal muscle
To identify BVES-interacting proteins from mouse skeletal muscle, we performed IP-mass from AAV9-BVES-HA injected mouse skeletal muscle using the anti-HA magnetic beads.
ORGANISM(S): Mus musculus (Mouse) 
2023-02-27 | PXD036346 | Pride
Bves Ap-ms Mouse Skeletal muscle 
TranscriptomicsCardiac-specific YAP activation improve cardiac function and survival in an experimental murine MI model
In this study, we used a cardiac-specific, inducible expression system to activate YAP in adult mouse heart. Activation of YAP in adult heart promoted cardiomyocyte proliferation and did not deleteriously affect heart function. Furthermore, YAP activation after myocardial infarction (MI) preserved h...
ORGANISM(S): Mus musculus 
2014-05-26 | E-GEOD-54612 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing of mouse forebrain cells 5 weeks after injections of a control AAV9 or a VEGF-C/D trap AAV9
Single-cell RNA sequencing of mouse forebrain cells 5 weeks after injections of a control AAV9 or a VEGF-C/D trap AAV9
PRJNA962187 | ENA
GenomicsNext-generation sequencing of RNA samples from the mice heart of Control, ABHD5-KO and ABHD5-KO transduced with AAV9 expressing HDAC4-NT (AAV9-NT)
Next-generation sequencing of RNA samples from the mice heart of Control, ABHD5-KO and ABHD5-KO transduced with AAV9 expressing HDAC4-NT (AAV9-NT)
PRJNA559559 | ENA
TranscriptomicsBeneficial effects of vascular endothelial growth factor B gene transfer in aged heart
VEGF family members are important regulators of vascular functions. Promoting VEGFA signalling in aged mice has been shown to delay various aging phenotypes and extend the survival of aged mice. Although there is profound knowledge on functions of VEGFA, VEGFB has not been investigated in the contex...
ORGANISM(S): Mus musculus 
2024-11-30 | E-MTAB-14595 | biostudies-arrayexpress
TranscriptomicsRNA-seq of heart from adult mice 4 and 48 hours post MycER activation compared controls
Aim: To determine RNA expression levels in heart tissues of mice 4 and 48 hours post Myc activation. Mice were systemically infected with a cardiomyocyte specific adeno associated virus (AAV9) at 4 to 6 weeks of age. Hearts were isolated from adult mice that had been infected with AAV9-Ccnt1 and we...
ORGANISM(S): Mus musculus 
2020-02-24 | E-MTAB-8462 | biostudies-arrayexpress
GenomicsATAC-seq Profiling of Adult Mouse Cardiomyocytes Treated with AAV9-cTnT-Rbm22 in MI Model
ATAC-seq Profiling of Adult Mouse Cardiomyocytes Treated with AAV9-cTnT-Rbm22 in MI Model
PRJNA1368826 | ENA
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