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GenomicsAstrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
PRJNA685549 | ENA
GenomicsInterleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis
PRJNA946811 | ENA
TranscriptomicsTranscriptional analysis of Calu-3 2B-4 cells stimulated with Interleukin-1a and TNFa.
Calu-3 2B-4 cells were stimulated with interleukin-1a or TNFa. Transcriptional analysis of the extracted RNA was done by microarray. Calu-3 2B-4 cells were washed with phosphate-buffered saline (PBS) and treated with either IL-1a (0.001ng/ml) or TNFa (0.05ng/ml) or mock diluted in PBS for 40 min at...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56678 | biostudies-arrayexpress
ProteomicsHuman cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
Adeno-associated viruses (AAVs) are foundational gene delivery tools for basic science and clinical therapeutics. However, lack of mechanistic insight, especially for engineered vectors created by directed evolution, can hamper their application. Here, we adapted an unbiased human cell microarray pl...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD045380 | Pride
Interleukin-3 Aav9 Il3 
TranscriptomicsTranscriptional analysis of Calu-3 2B-4 cells stimulated with Interleukin-1a and TNFa.
Calu-3 2B-4 cells were stimulated with interleukin-1a or TNFa. Transcriptional analysis of the extracted RNA was done by microarray.
ORGANISM(S): Homo sapiens 
2014-08-31 | GSE56678 | GEO
ProteomicsLC-MS/MS identification of interactors of Interleukin-1 Receptor Associated Kinase 3 (IRAK3)
Imterleukin-1 Receptor Associated Kinase 3 (IRAK3) acts as a negative regulator of interleukin-1 receptor and Toll-like receptors signalling by preventing dissociation of IRAKs from myddosome complex, therefore disabling production of proinflammatory cytokines. Since the molecular mode of IRAK3 acti...
ORGANISM(S): Homo sapiens (Human) 
2026-08-23 | PXD030321 | Pride
Thp-1 Irak3 Co-ip Lc-ms/ms 
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 I
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64201 | biostudies-arrayexpress
TranscriptomicsAstrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Communication within the glial cell ecosystem is essential for neuronal and brain health1–3. The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and neurofibrillary tau in the brains of individuals with Alzheimer’s disease (AD) is poorly understood, despite growing aware...
ORGANISM(S): Mus musculus 
2021-06-02 | GSE163289 | GEO
GenomicsRUNX1 loss renders hematopoietic and leukemic cells dependent on interleukin-3 and sensitive to JAK inhibition [ATAC-seq]
RUNX1 loss renders hematopoietic and leukemic cells dependent on interleukin-3 and sensitive to JAK inhibition [ATAC-seq]
PRJNA970296 | ENA
GenomicsRUNX1 loss renders hematopoietic and leukemic cells dependent on interleukin-3 and sensitive to JAK inhibition [RNA-seq]
RUNX1 loss renders hematopoietic and leukemic cells dependent on interleukin-3 and sensitive to JAK inhibition [RNA-seq]
PRJNA970294 | ENA
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