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ProteomicsLC-MS/MS identification of interactors of Interleukin-1 Receptor Associated Kinase 3 (IRAK3)
Imterleukin-1 Receptor Associated Kinase 3 (IRAK3) acts as a negative regulator of interleukin-1 receptor and Toll-like receptors signalling by preventing dissociation of IRAKs from myddosome complex, therefore disabling production of proinflammatory cytokines. Since the molecular mode of IRAK3 acti...
ORGANISM(S): Homo sapiens (Human) 
2026-08-23 | PXD030321 | Pride
Thp-1 Irak3 Co-ip Lc-ms/ms 
GenomicsIRAK3 in salmonid fish
IRAK3 inhibits TLR-dependent NF-kappaB activation in salmonid fish
PRJEB29555 | ENA
UnknownIRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity.
Not available
S-EPMC6820782 | biostudies-literature
UnknownModulation of Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3.
Not available
S-EPMC8909980 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq of splenocytes from wild-type and Irak3-deficient mice after anti-PD-1-mediated clearance of EO771 tumours and tumour re-challenge
IRAK3 (IRAK-M) is a negative regulator of innate immune signalling. To study how Irak3 deficiency shapes systemic immune memory after immunotherapy-induced tumour rejection, wild-type and germline Irak3 knockout mice that had cleared subcutaneous EO771 breast tumours under anti-PD-1 treatment were r...
ORGANISM(S): Mus musculus 
2026-10-02 | GSE347249 | GEO
UnknownDimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.
Not available
S-EPMC7955167 | biostudies-literature
UnknownIRAK3 is upregulated in rheumatoid arthritis synovium and delays the onset of experimental arthritis.
Not available
S-EPMC12074951 | biostudies-literature
GenomicsSingle-cell RNA-seq of splenocytes from wild-type and Irak3-deficient mice after anti-PD-1-mediated clearance of EO771 tumours and tumour re-challenge
Single-cell RNA-seq of splenocytes from wild-type and Irak3-deficient mice after anti-PD-1-mediated clearance of EO771 tumours and tumour re-challenge
PRJNA1529198 | ENA
UnknownHypermethylation of the IRAK3-Activated MAPK Signaling Pathway to Promote the Development of Glioma.
Not available
S-EPMC7425661 | biostudies-literature
UnknownIL-1 receptor-associated kinase 3 (IRAK3) in lung adenocarcinoma predicts prognosis and immunotherapy resistance: involvement of multiple inflammation-related pathways.
Not available
S-EPMC11484737 | biostudies-literature
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