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MetabolomicsCD5L inhibits allergic airway inflammation by lysophosphatidylcholine-induced ILC2 apoptosis

Group 2 innate lymphoid cells (ILC2s) play key roles in allergic asthma development. We have previously revealed the inhibitory effect of CD5 antigen-like protein (CD5L) on allergic airway inflammation. Here, we analyzed the effect of CD5L on ILC2s.

2025-09-04 | MTBLS12937 | MetaboLights
ProteomicsAmino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses - WT ILC2
Group 2 innate lymphoid cells (ILC2) are functionally poised, tissue-resident lymphocytes that respond rapidly to damage and infection at mucosal barrier sites. ILC2 reside within complex microenvironments where they are subject to cues from both the diet and invading pathogens – including helminths...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-22 | PXD038792 | Pride
Ilc2 Immunology 
ProteomicsAmino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses - SLC7A5 and SLC7A8 KO
Group 2 innate lymphoid cells (ILC2) are functionally poised, tissue-resident lymphocytes that respond rapidly to damage and infection at mucosal barrier sites. ILC2 reside within complex microenvironments where they are subject to cues from both the diet and invading pathogens – including helminths...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-22 | PXD038786 | Pride
Ilc2 Immunology 
TranscriptomicsBulk RNA-Seq of lung Type 2 Innate Lymphoid cells (ILC2) in response to papain
Type 2 Innate Lymphoid cells (ILC2) play a crucial role in allergic airway inflammation. To identify transcriptional differences between naive ILC2 and allergen induced ILC2, mice were challenged with PBS control or papain on days 0, 3, 6 and 13. On day 14 ILC2 were isolated, sort-purified and sequ...
ORGANISM(S): Mus musculus 
2025-12-10 | E-MTAB-15989 | biostudies-arrayexpress
TranscriptomicsBulk RNA-Seq of lung Type 2 Innate Lymphoid cells (ILC2) in response to Alternaria alternata
Type 2 Innate Lymphoid cells (ILC2) play a crucial role in allergic airway inflammation. To identify transcriptional differences between naive ILC2 and allergen induced ILC2, mice were challenged with PBS control or Alternaria alternate on days 0, 3, 6 and 13. On day 14 ILC2 were isolated, sort-pur...
ORGANISM(S): Mus musculus 
2025-12-10 | E-MTAB-15967 | biostudies-arrayexpress
TranscriptomicsExpression data of ILC2 cells from Ets1-deleted and littermate control mice
The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2 ILC2 cells isolated from ETS1-deleted or litter mate control mice were cultured on OP9-DL1 with IL-7 and IL-33. Subsequently, RNA from ICOS+ cells was extracted, labelled and hybridized to Affymetrix...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-79742 | biostudies-arrayexpress
GenomicsATAC-seq of bone marrow ILC2 lineages and Lung ILC2 steady state
ATAC-seq of bone marrow ILC2 lineages and Lung ILC2 steady state
PRJNA902402 | ENA
TranscriptomicsRNA-Seq of Group 2 innate lymphoid cells (ILC2) from lung and lymph node
Group 2 innate lymphoid cells (ILC2) promote the production of a type-2 immunological environment in the uterus and have tissue-specific gene signatures that change with pregnancy.
ORGANISM(S): Mus musculus 
2023-04-15 | E-MTAB-5806 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Group 2 innate lymphoid cells (ILC2) from uterine tissue (Virgin, E9.5, E18.5)
Group 2 innate lymphoid cells (ILC2) promote the production of a type-2 immunological environment in the uterus and have tissue-specific gene signatures that change with pregnancy.
ORGANISM(S): Mus musculus 
2023-04-15 | E-MTAB-5803 | biostudies-arrayexpress
TranscriptomicsHuman ILC2 cells stimulated with IL-25, IL-33, or TSLP
ILC2 cells are a newly described cell type whose biology and contribution to disease are poorly understood. ILC2 cells are activated by allergens, viral infection, and/or epithelial damage via IL-33 and IL-25. ILC2 cells require IL-2, IL-7, IL-25 and IL-33 for their survival and expansion. In mice, ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-45458 | biostudies-arrayexpress
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