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TranscriptomicsRNA-seq analysis of IMQ-treated wt and Trex2-/- skin
TREX2 is a keratinocyte specific 3’-deoxyribonuclease that participates in the maintenance of skin homeostasis upon damage. This transcriptome analysis identified multiple genes and pathways deregulated by TREX2 loss in the IMQ-induced psoriasis-like model in mouse skin. mRNA sequencing of 5 biolo...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-74528 | biostudies-arrayexpress
GenomicsMolecular analysis in imiquimod (IMQ)-induced psoriasis model
Molecular analysis in imiquimod (IMQ)-induced psoriasis model
PRJNA639875 | ENA
TranscriptomicsMolecular analysis in imiquimod (IMQ)-induced psoriasis model
The mechanisms underlying pruritus of imiquimod (IMQ)-induced psoriasis remain poorly understood. In this study, we investigated whether there are certain key signaling molecules downstream of the recently identified peptides mediating itch in the spinal cord. We investigated the changes in the tras...
ORGANISM(S): Mus musculus 
2023-06-15 | GSE152637 | GEO
ProteomicsClove (Syzygium aromaticum) and its bioactive constituent eugenol alleviate psoriatic inflammation by modulating the IL-36/IL-17A axis: A proteomic and mechanistic study
An imiquimod (IMQ)-induced psoriasis-like mouse model was employed to assess the therapeutic effects of orally administered clove extract and eugenol. iTRAQ-based LC–MS/MS proteomics were performed to identify molecular alterations, followed by bioinformatics analyses.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD077433 | Pride
Syzygium aromaticum  eugenol  psoriasis  interleukin-17a  interleukin-36  proteomics 
TranscriptomicsExpression data from IMQ-induced psoriasis-like skin inflammation in miR-146a-/- and C57BL6J mice
miR-146a acts as a negative feedback regulator of inflammation. To investigate the role of miR-146a in psoriasis psoriasiform skin inflammation was indeuced in Mir-146a-/- and wild type mice (C57BL6J) by topical applciation of imiquimod (IMQ)-cream (Aldara). Gene expression profiling (Affymetrix)...
ORGANISM(S): Mus musculus 
2016-02-19 | E-GEOD-78057 | biostudies-arrayexpress
ProteomicsMDA5 signaling in splenic B cells from imiquimod-induced lupus mouse model with proteomics study
Abstract Introduction Several environmental stimuli may influence lupus, especially viral infection. We utilize an imiquimod-induced lupus mouse model focusing on TLR7 pathway and use proteomics analysis to figure out the specific pathway related to viral infection and its related protein expression...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034855 | Pride
Mouse model B cell Imiquimod (imq) Proteomics Lupus Mda5 
TranscriptomicsStimulation of isolated plasmacytoid dendritic cells (pDCs) with TLR9 agonist CpG C (CpG) and TLR7 agonist imiquimod (IMQ)
The purpose of this experiment was to assess the genes upregulated when pDCs were stimulated with TLR7 agonist imiquimod and TLR9 agonist CpG C. pDCs were isolated from six healthy donors by FACS sorting, and were stimulated with CpG and imiquimod for 18 hours, after which RNA was extracted for next...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-79272 | biostudies-arrayexpress
ProteomicsMatrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model
Inflammation and autoimmunity are known as central processes in many skin diseases, including psoriasis. It is therefore important to develop pre-clinical models that describe disease-related aspects to enable testing of pharmaceutical drug candidates and formulations to essentially develop safe and...
ORGANISM(S): Mus Musculus 
2025-10-31 | PXD046049 | panorama
GenomicsLow-input mRNA Sequencing Analysis of Epidermal Langerhans cells (LC) from Murine Imiquimod (IMQ)-Induced Psoriasis-Like Dermatitis
Low-input mRNA Sequencing Analysis of Epidermal Langerhans cells (LC) from Murine Imiquimod (IMQ)-Induced Psoriasis-Like Dermatitis
PRJNA681231 | ENA
GenomicsInfluence of rYopM treatment on IMQ-induced psoriasiform dermatitis
Influence of rYopM treatment on IMQ-induced psoriasiform dermatitis
PRJNA486825 | ENA
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