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MetabolomicsReversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies
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ORGANISM(S): Mus musculus 
ST001838 | MetabolomicsWorkbench
MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
TranscriptomicsSugar turns benefit of cholesterol into immune evasion in Helicobacter pylori infected C57BL/6 mice
Following the initial demonstration of Helicobacter pyloriâ??s pathogenic potential, evidence has been accumulated that H. pylori is the leading cause of gastric ulcers, carcinoma and lymphoma3. Cholesterol is a physiological constituent of membranes critical for their biophysical properties, but is...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3878 | biostudies-arrayexpress
ProteomicsNew insights into hypoxia-driven metabolic, anti-apoptotic and immune evasion strategies of primary human myeloma cells
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-17 | MSV000084470 | MassIVE
TranscriptomicsTranscription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines
The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to i...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2774 | biostudies-arrayexpress
TranscriptomicsGlobal changes in Staphylococcus aureus gene expression in human blood provide insight into mechanisms of immune evasion and virulence
Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote bacteremia and survival in human blood is ...
ORGANISM(S): Staphylococcus aureus 
2011-08-25 | E-GEOD-25454 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Jurkat CF4+ T cells transfected with simian immunodeficiency virus Nef cells leads to a molecular profile of viral persistence and immune evasion.
Jurkat T cell line was transfected with SIV Nef controlled by an inducible promoter system. Nef was induced by addition of 10 micromolar pronasterone A and gene expression values were determined after 24 hrs. Control Jurkat cells were untransfected and treated with 10 micromolar pronasterone A and g...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4785 | biostudies-arrayexpress
ModelsWilkie2013b - immune-induced cancer dormancy and immune evasion-basic
The paper describes a basic model of immune-induced cancer dormancy and immune evasion. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion Kathleen P. Wilkie and Philip Hahnfeldt Int...
2024-09-02 | BIOMD0000000751 | BioModels
Immuno-oncology 
ModelsWilkie2013r - immune-induced cancer dormancy and immune evasion-resistance
The paper describes a model of immune-induced cancer dormancy and immune evasion with resistance. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion Kathleen P. Wilkie and Philip Hah...
2024-09-02 | BIOMD0000000752 | BioModels
Immuno-oncology 
GenomicsDNA Methylation loss coupled with mitotic cell division promotes immune evasion of tumours with high mutation load
Mitotic cell division increases tumour mutation burden and copy number load with a positive and inverse correlation, respectively, with the clinical benefit of immunotherapy. Markers of cell division correlate also with genomic demethylation involving methylation loss in late-replicating partial met...
EGAS00001003731 | EGA
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