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MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
MetabolomicsMetabolomics of immunoglobulin-producing cells in IgA nephropathy
Not available
ORGANISM(S): Homo sapiens 
ST000560 | MetabolomicsWorkbench
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
TranscriptomicsRelation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. La...
ORGANISM(S): Homo sapiens 
2005-08-27 | E-GEOD-3211 | biostudies-arrayexpress
TranscriptomicsAllele specific analysis of the immunoglobulin heavy chain locus by simultaneous analysis of the productive and the non-productive allele through paired-end 4C sequencing analysis in mature B cells
In developing B cells the immunoglobulin heavy chain (IgH) locus is thought to move from repressive to permissive chromatin compartments to facilitate its scheduled rearrangement. In mature B cells, maintenance of allelic exclusion has been proposed to involve recruitment of the non-productive IgH a...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-47128 | biostudies-arrayexpress
GenomicsDiversity of the human immunoglobulin loci
Diversity of the human immunoglobulin loci
PRJEB2201 | ENA
ProteomicsSPIO corona - Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles
Identification of corona proteins in serum and plasma of healthy donors
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD011781 | Pride
Spio Plasma Serum Nanoparticles 
TranscriptomicsAllele specific analysis of the immunoglobulin heavy chain locus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-47129 | biostudies-arrayexpress
GenomicsRevisiting proliferative glomerulonephritis with monoclonal immunoglobulin deposits through immunoglobulin repertoire sequencing
Immunoglobulin Repertoire Analysis in PGNMID
PRJEB88838 | ENA
TranscriptomicsTranscription profiling of human immunoglobulin mutation genotype in B Cell chronic lymphocytic leukaemia
The Journal of Experimental Medicine, Volume 194, Number 11, December 3, 2001 1639-1648 Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia Andreas Rosenwald1, Ash A. Alizadeh2, George Widhopf5, Richard Simon6, R. Eric Davis1, Xin Yu1, ...
ORGANISM(S): Homo sapiens 
2005-06-29 | E-SMDB-1002 | biostudies-arrayexpress
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