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ProteomicsInfluence of immunoglobulin genotypes on the elicitation of SARS CoV-2 neutralizing antibodies
The human immunoglobulin heavy chain (IGH) locus is exceptionally polymorphic with high allelic diversity of variable (V) genes and structural variation affecting large regions of the locus. Thus, our germline IGHV gene and allele content is highly personal, which may influence how we respond to inf...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031945 | Pride
Neutralizing antibody Sars-cov-2 Immunoglobulin germline allele Single nucleotide polymorphism Copy number variation Hdx-ms 
UnknownHuman immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.
Not available
S-EPMC11384754 | biostudies-literature
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in huma...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005704 | Pride
Human Antigen presentation Ltq orbitrap elite Mhc class i 
UnknownGermline polymorphisms and alternative splicing of human immunoglobulin light chain genes.
Not available
S-EPMC8517844 | biostudies-literature
UnknownImmunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
Not available
S-EPMC9742198 | biostudies-literature
UnknownNovel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches.
Not available
S-EPMC11703713 | biostudies-literature
UnknownCharacterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains.
Not available
S-EPMC12274646 | biostudies-literature
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in hu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-27 | MSV000098361 | MassIVE
UnknownNeutralizing Antibody Induction Associated with a Germline Immunoglobulin Gene Polymorphism in Neutralization-Resistant SIVsmE543-3 Infection.
Not available
S-EPMC8235048 | biostudies-literature
UnknownAssociation between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
Not available
S-EPMC5437274 | biostudies-literature
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