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MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
MetabolomicsMitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer_GlnFlux_untargeted metabolites

Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. H...

2025-09-29 | MTBLS13074 | MetaboLights
MetabolomicsMitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer_targeted metabolites

Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. H...

2025-09-29 | MTBLS13076 | MetaboLights
MetabolomicsMitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer_A549 cell culture_untargeted metabolites_U_13gln/glc

Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. H...

2025-09-29 | MTBLS13075 | MetaboLights
MetabolomicsPolyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells (Part 3)
Not available
ORGANISM(S): Mus musculus 
ST001998 | MetabolomicsWorkbench
MetabolomicsPolyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST001997 | MetabolomicsWorkbench
MetabolomicsPolyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST001996 | MetabolomicsWorkbench
MetabolomicsPolyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells (Part 4)
Not available
ORGANISM(S): Mus musculus 
ST001999 | MetabolomicsWorkbench
TranscriptomicsThe ß-importin KAP8 (Pse1/Kap121) is required for nuclear import of the cellulase transcriptional regulator XYR1, asexual sporulation and stress resistance in Trichoderma reesei
The ascomycete Trichoderma reesei is an industrial producer of cellulolytic and hemicellulolytic enzymes and also serves as a model for investigations on these enzymes and their genes. Most of them are obligatorily dependent on the Zn(II)Cys(VI) transcriptional activator XYR1. XYR1 is constitutively...
ORGANISM(S): Trichoderma reesei 
2015-03-03 | E-GEOD-59600 | biostudies-arrayexpress
ProteomicsInteractors of trapped protein from mitochondria from HeLa cells with stalled import TMT-MS
This study explores the consequences of import failure in mammalian cells; wherein, blocking the import machinery has profound effects on mitochondrial ultra-structure and dynamics, but, surprisingly, does not impact import. The explanation is an astonishing response involving intercellular mitochon...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD040098 | Pride
Mitochondria Hela Import Galactose 
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