Importin inhibition

Show results for

Transcriptomics (258)
Unknown (100)
Genomics (32)
Proteomics (6)
Other (1)

Organisms

Homo sapiens (126)
Mus musculus (95)
Rattus norvegicus (17)
Arabidopsis thaliana (7)
Bos taurus (6)
Plasmodium falciparum (4)
Hordeum vulgare (3)
Gallus gallus (3)
Drosophila melanogaster (2)
Lathyrus sativus (1)
Populus tremula (1)
Callithrix jacchus (1)
Erwinia amylovora (1)
Fusobacterium nucleatum (1)
Macaca mulatta (1)
Collimonas fungivorans (1)
Chlamydomonas reinhardtii (1)
Nicotiana benthamiana (1)
Listeria monocytogenes (1)
Mesocricetus auratus (1)
Salmo salar (1)
Solanum lycopersicum (1)
Clostridioides difficile (1)
Anas platyrhynchos (1)
Escherichia coli K-12 (1)
Pseudomonas aeruginosa (1)
Actinoplanes sp. SE50/110 (1)
Escherichia coli (1)
Saccharomyces cerevisiae (1)
Candida albicans (1)

Organisms

Homo sapiens (4)
Mus musculus (1)

Repository

biostudies-arrayexpress (280)
geo (5)
ENA (5)
pride (4)
EGA (2)
MassIVE (2)
GPMDB (1)

Tissue

Cell culture (3)
Brain (1)
Erythrocyte (1)

Disease

Phyllodes tumor (1)
Blumeria graminis hordei (powdery mildew) inoculation (1)
Infiltrating ductal carcinoma (1)
Colon adenocarcinoma (1)
S enteritidis (1)
Not Available (1)
Breast cancer (1)
Disease free (1)

Technology Type

Mass Spectrometry (4)
Affinity purification coupled with mass spectrometry proteomics (2)
Gel-based experiment (1)
Shotgun proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (5)
Illumina HiSeq 4000 (5)
NextSeq 500 (4)
Illumina Genome Analyzer IIx (3)
Illumina HiSeq 2500 (3)
Illumina HiSeq 2000 (3)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
GenePix 4000B [Axon Instruments] (2)
Illumina NovaSeq X (2)
Python (1)
Nugen Ovation SPIA; Wafergen’s Apollo liquid handler; KAPA Hyper Prep Library Kit (1)
QIAGEN TissueLyser II (1)
Isoflurane euthanasia chamber (1)
Chromium Next GEM Chip G (1)
10X v3 (1)
(Make:PerkinElmer,Model:ScanArray 4000XL) (1)
HiSeq X Five (1)
Other (1)
G2565AA DNA microarray scanner [Agilent] (1)
Axon- GenePix4000B (1)
G2505B DNA microarray scanner (1)
Affymetrix Fluidics Station 400 (1)
DNBSEQ-G400 (1)
Illumina MiSeq (1)
NextSeq 550 (1)
Instrument (1)
LTQ (1)
LTQ Orbitrap Elite (1)
LTQ Orbitrap XL (1)
Q Exactive (1)

Publication Date

2015 (52)
2016 (42)
2014 (31)
2012 (27)
2013 (25)
2010 (20)
2008 (19)
2011 (14)
2025 (8)
2009 (8)
2026 (6)
2022 (6)
2006 (6)
2018 (5)
2007 (5)
2019 (4)
2024 (3)
2023 (3)
2021 (2)
2020 (2)
2004 (2)
2005 (1)

First Public Date

2023 (2)
2022 (1)
2019 (1)
2016 (1)

Study type

Transcription profiling by array (159)
RNA-seq of coding RNA (71)
ChIP-seq (22)
Transcription profiling by tiling array (4)
RNA-seq of total RNA (4)
ChIP-chip by tiling array (3)
RNA-seq of coding RNA from single cells (3)
RNA-seq of non coding RNA (3)
Other (2)
Methylation profiling by array (2)
High-throughput sequencing (1)
RNAi profiling by array (1)
Transcription profiling by RT-PCR (1)
Comparative genomic hybridization by array (1)
Methylation profiling by high throughput sequencing (1)

Release Date

2015 (56)
2016 (44)
2014 (35)
2012 (31)
2013 (28)
2010 (26)
2008 (21)
2011 (17)
2022 (13)
2021 (13)
2025 (12)
2023 (10)
2020 (10)
2009 (10)
2018 (9)
2017 (9)
2024 (8)
2019 (7)
2007 (7)
2006 (6)
2026 (5)
2004 (2)
2005 (1)

Lab affiliation

George Washington University (1)
IRIC-Université de Montréal (1)
Institute of Molecular Biology, Academia Sinica (1)
La Trobe Institute for Molecular Science, Department of Biochemistry & Chemistry, La Trobe University, Melbourne, VIC, 3073, Australia. (1)

Previous page
1 / 40
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 40
Next page

Sort by:

Relevance

Page size

CDK9 interacts with a RanGTP-NEMP1-Importin-β complex to regulate erythroid enucleation

Erythroid enucleation is the final stage of erythroid terminal differentiation and involves the separation of an orthochromatic erythroblast into two daughter cells; a pyrenocyte containing the extruded nucleus, and a reticulocyte that will become a red blood cell. Our previous work identified CDK9 ...

ORGANISM(S): Homo sapiens (Human)

2026-04-01 | PXD072077 | Pride

Parallel PP2A activation and importin inhibition by sphingosine and related anti-neoplastic compounds

Sphingolipids enforce homeostatic cell growth in eukaryotes1,2. Phytosphingosine triggers an adaptive growth arrest in heat-stressed yeast while ceramide and its precursor/product sphingosine function as tumor suppressors in mammalian cells. Consistent with this, the constrained cyclic analogs of sp...

ORGANISM(S): Mus musculus (Mouse)

2025-05-14 | PXD036429 | Pride

Pp2a activation Importin inhibition Sphingosine Chemoproteomics

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import.

Not available

S-EPMC11585640 | biostudies-literature

Regulation of mitotic spindle assembly factor NuMA by Importin-β.

Not available

S-EPMC5674899 | biostudies-literature

Importin subunit beta-1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation.

Not available

S-EPMC11705758 | biostudies-literature