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ProteomicsCDK9 interacts with a RanGTP-NEMP1-Importin-β complex to regulate erythroid enucleation
Erythroid enucleation is the final stage of erythroid terminal differentiation and involves the separation of an orthochromatic erythroblast into two daughter cells; a pyrenocyte containing the extruded nucleus, and a reticulocyte that will become a red blood cell. Our previous work identified CDK9 ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD072077 | Pride
Enucleation Cdk9 Erythropoiesis Importin-beta 
GenomicsRole of Importin alpha3 and importin beta 1 in the peripheral sensory neurons
Role of Importin alpha3 and importin beta 1 in the peripheral sensory neurons
PRJNA510795 | ENA
ProteomicsC9orf72 arginine-rich dipeptide repeat proteins disrupt importin beta-mediated nuclear import
Disruption of nucleocytoplasmic transport (NCT), including mislocalization of the importin beta cargo, TDP-43, is a hallmark of amyotrophic lateral sclerosis (ALS), including ALS caused by a hexanucleotide repeat expansion in C9orf72. However, the mechanism(s) remain unclear. Importin beta and its c...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD015656 | Pride
Importin beta Nuclear transport Amyotrophic lateral sclerosis C9orf72 
TranscriptomicsRole of Importin alpha3 and importin beta 1 in the peripheral sensory neurons
Project 1: Overall, our work showed using three independent approaches that importin α3 mice have a lower basal sensitivity for noxious heat, show a delayed response to capsaicin-induced pain and recover faster with less pain from a neuropathic pain injury. The data further identified a novel role f...
ORGANISM(S): Mus musculus 
2025-12-01 | GSE124116 | GEO
UnknownThe importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex.
Not available
S-EPMC2859540 | biostudies-literature
UnknownConformational selection in the recognition of the snurportin importin beta binding domain by importin beta.
Not available
S-EPMC6013741 | biostudies-literature
ProteomicsSILAC-Tp (12 importins) - Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
Importin-beta family proteins are nucleocytoplasmic transport receptors (NTRs), and they transport most nuclear proteins as their cargoes into and out of the nuclei. Human cells have 20 species of importin-beta family NTRs, of which 10 (importin-beta, transportin-1, -2, -SR, importin-4, -5, -7, -8, ...
ORGANISM(S): Homo sapiens (Human) 
2017-01-20 | PXD004655 | Pride
Nuclear transport Cargo Silac Transportin Importin Human Lc-ms/ms 
UnknownRan modulates allosteric crosstalk between importin β surfaces.
Not available
S-EPMC12749841 | biostudies-literature
ProteomicsSILAC-Tp (importin-alpha/beta +MA-5)
HeLa-S3 adherent cells were labeled with u-13C6 Lys and u-13C6 Arg and the cell membranes were permeabilized. Proteins in unlabeled HeLa-S3 nuclear extract depleted of all nuclear transport receptors (NTRs) were transported into the nuclei of the permeabilized cells (i) in the absence of any NTR, (i...
ORGANISM(S): Homo Sapiens (human) 
2026-02-15 | PXD049395 | JPOST Repository
UnknownRegulation of mitotic spindle assembly factor NuMA by Importin-β.
Not available
S-EPMC5674899 | biostudies-literature
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