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TranscriptomicsHeLa cells: overexpression of importin alpha2
To test whether nuclear importin alpha2 can regulate transcription, we sought to examine gene expression changes in cells with nuclear accumulation of importin alpha2 by performing microarray analysis. We designed an experiment in which EGFP-fused full-length importin alpha2 was transfected into HeL...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-25303 | biostudies-arrayexpress
ProteomicsExtensive identification and in-depth validation of importin 13 cargoes
Importin 13 is a bidirectional transport receptor that mediates both nuclear import and export of proteins. To expand the range of human importin 13 cargoes, we performed importin 13 binding experiments in combination with quantitative stable isotope labeling with amino acids in cell culture (SILAC)...
ORGANISM(S): Homo sapiens (Human) 
2018-04-20 | PXD008459 | Pride
Importin 13 Human Silac Nucleocytoplasmic transport Nuclear transport receptor 
ProteomicsSILAC-Tp (12 importins) - Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
Importin-beta family proteins are nucleocytoplasmic transport receptors (NTRs), and they transport most nuclear proteins as their cargoes into and out of the nuclei. Human cells have 20 species of importin-beta family NTRs, of which 10 (importin-beta, transportin-1, -2, -SR, importin-4, -5, -7, -8, ...
ORGANISM(S): Homo sapiens (Human) 
2017-01-20 | PXD004655 | Pride
Nuclear transport Cargo Silac Transportin Importin Human Lc-ms/ms 
ProteomicsAnti-Flag AP-MS of cytoplasmic 3×Flag-importin α1 complexes in HeLa S3 cells
To identify binding partners of importin α1 in the cytoplasm, co-immunoprecipitation using an anti-Flag antibody in the cytoplasmic fraction of 3×Flag–importin α1-inducible HeLaS3 cells.
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD076745 | Pride
Nuclear localization signal Helas3 Importin Nls 
ProteomicsSILAC-Tp (12 importins)
Importin-beta family proteins are nucleocytoplasmic transport receptors (NTRs), and they transport most nuclear proteins as their cargoes into and out of the nuclei. Human cells have 20 species of importin-beta family NTRs, of which 10 (importin-beta, transportin-1, -2, -SR, importin-4, -5, -7, -8, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080815 | MassIVE
ProteomicsNuclear and total proteins in THP-1 cell differentiation
THP-1 monocyte-like suspension cells can be differentiated into macrophage-like adherent cells by TPA (PMA) treatment. Proteomic analysis was carried out on (i) normal THP-1 cells, (ii) THP-1 cells in which KPNA1 (importin-alpha5) was knocked down or not by siRNA, and (iii) THP-1 TetOn-KPNA2 (import...
ORGANISM(S): Homo Sapiens (human) 
2025-02-15 | PXD049401 | JPOST Repository
GenomicsRole of Importin alpha3 and importin beta 1 in the peripheral sensory neurons
Role of Importin alpha3 and importin beta 1 in the peripheral sensory neurons
PRJNA510795 | ENA
GenomicsDeciphering the role of importin alpha in mammalian central neurons - Hippocampal gene expression profiling in importin alpha5-deleted mice
Deciphering the role of importin alpha in mammalian central neurons - Hippocampal gene expression profiling in importin alpha5-deleted mice
PRJNA417195 | ENA
GenomicsImportin α7 deficiency causes infertility in male mice by disrupting spermatogenesis
Importin α7 deficiency causes infertility in male mice by disrupting spermatogenesis
PRJNA675014 | ENA
GenomicsGenetic screen for neuropathic pain study in importin alpha3 knock out mice
Genetic screen for neuropathic pain study in importin alpha3 knock out mice
PRJNA565766 | ENA
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