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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
TranscriptomicsEffects of in vitro maturation on oocyte gene expression
In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of non human primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below s...
ORGANISM(S): Macaca mulatta 
2009-05-20 | E-GEOD-11895 | biostudies-arrayexpress
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
TranscriptomicsTranscriptome profile of in vitro produced blastocysts derived from in vitro matured oocytes exposed to exogenous interleukin-6
This study explores the biological role of interleukin-6 (IL-6) as a supplement during in vitro maturation (IVM) of porcine oocytes, aiming to enhance embryonic development and reduce apoptosis following in vitro fertilization (IVF). The objective was to determine whether IL-6 supplementation alters...
ORGANISM(S): Sus scrofa 
2025-06-30 | E-MTAB-15241 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of bovine cumulus cells during first 6 hrs of in vitro maturation
Study the effect of in vitro maturation system on the transcriptomics of bovine cumulus cells during incubation of first 6 hrs. 3 biological replicates of cumulus cells derived from cumulus oocyte complexes (COCs) after 6 hrs of in vitro matutaion(Ct-6H) vs. cumulus cells before maturation (Ct-0H, R...
ORGANISM(S): Bos taurus 
2015-07-01 | E-GEOD-67969 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles in Immature and In vitro matured bovine Oocytes
In cattle, almost all fully grown vesicle stage oocytes (GV) have the ability to resume meisos, develop to Metaphase II stage (MII), support fertilization and progress through the early embryonic cycles in vitro. Yet without intensive selection, the majority fail to develop to the blastocyst stage. ...
ORGANISM(S): Bos taurus 
2011-04-25 | E-GEOD-23449 | biostudies-arrayexpress
TranscriptomicsExtensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome
The elaboration of a quality oocyte is integrally linked to the correct developmental progression of cumulus cell phenotype. In humans and non-human primates, oocyte quality is diminished with in vitro maturation. To determine the changes in gene expression in rhesus monkey cumulus cells (CC) that o...
ORGANISM(S): Macaca mulatta 
2011-05-22 | E-GEOD-25288 | biostudies-arrayexpress
ProteomicsTreatment of human oocytes with extracellular vesicles from follicular fluid during rescue in vitro maturation enhances maturation rates and modulates oocyte proteome and ultrastructure
This project aimed to elucidate whether human follicular fluid–derived extracellular vesicles (ffEVs) enhance oocyte maturation during rescue in vitro maturation (rIVM). We characterised the protein cargo of ffEVs isolated from follicles containing oocytes at different maturation stages (GV, GVBD, a...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD073018 | Pride
Follicular fluid Extracellular vesicles Human oocyte In vitro maturation Single-cell proteomic analysis 
ProteomicsAnalysis of the proteome of individual equine cumulus complexes after maturation in-vitro and in-vivo
Maturation of oocytes under in-vitro conditions (IVM) results in impaired developmental competence compared to oocytes matured in-vivo. Oocytes are closely coupled to their cumulus complex (COC) with a bidirectional exchange of metabolites. Therefore, elucidation of aberrations in cumulus metabolism...
ORGANISM(S): Equus caballus (Horse) 
2019-11-12 | PXD011086 | Pride
In-vitro Cumulus cells In-vivo Lc-ms/ms Ivm 
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