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ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018703 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018710 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
GenomicsPalmitoylation negatively regulates AEG-1 function
Palmitoylation negatively regulates AEG-1 function
PRJNA888790 | ENA
ProteomicsPharmacological Targeting of DHHC9-Mediated STRN4 Palmitoylation to Suppress YAP-Driven Cancer Metastasis
Protein S-palmitoylation, a dynamic and reversible post-translational modification involving the attachment of palmitate to cysteine residues, is a key regulator of protein functionality and cellular signaling. Dysregulation of this modification has emerged as a critical driver of cancer progression...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD060045 | Pride
Human Proteomics Protein s-palmitoylation 
GenomicsSELENOK-Dependent CD36 Palmitoylation Regulates Microglial Functions and Aβ Phagocytosis
SELENOK-Dependent CD36 Palmitoylation Regulates Microglial Functions and Aβ Phagocytosis
PRJNA1073397 | ENA
TranscriptomicsFlotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.
Flotillin-1 contributes to invasion and metastasis in triple negative breast cancer (TNBC). Palmitoylation, the process of conjugating palmitoyl-CoA to proteins, plays an essential role in protein stability and trafficking. Flotillin-1 is modified by palmitoylation, however, the role of its palmitoy...
ORGANISM(S): Homo sapiens 
2024-03-15 | GSE236971 | GEO
GenomicsZDHHC5-Mediated BRAF Palmitoylation Drives KRASG12C-Inhibitor Resistance and Sustains Oncogenic MAPK Signalling
ZDHHC5-Mediated BRAF Palmitoylation Drives KRASG12C-Inhibitor Resistance and Sustains Oncogenic MAPK Signalling
PRJNA1269486 | ENA
GenomicsZDHHC8-mediated β-catenin palmitoylation promotes WNT signaling activation and drives cisplatin resistance in osteosarcoma
ZDHHC8-mediated β-catenin palmitoylation promotes WNT signaling activation and drives cisplatin resistance in osteosarcoma
PRJNA1415771 | ENA
TranscriptomicsZDHHC5-Mediated BRAF Palmitoylation Drives KRASG12C-Inhibitor Resistance and Sustains Oncogenic MAPK Signalling
Therapeutic resistance to single-agent targeted therapies (e.g., KRASG12C inhibitors) frequently arises in tumors through adaptive mechanisms such as cellular plasticity and genetic instability. Here, we demonstrated that KRASG12C inhibitors induce BRAF membrane localization, leading to MAPK pathway...
ORGANISM(S): Homo sapiens 
2025-06-02 | GSE298455 | GEO
TranscriptomicsPalmitoylation negatively regulates AEG-1 function
In vitro studies revealed that AEG-1 is palmitoylated at cysteine at a.a. 75 position. In order to check how palmitoylation regulates AEG-1 function in vivo we generated a knockin moue using CRISPR/Cas9 taking in which cysteine 75 was mutated to serine (AEG-1-C75S). Hepatocytes were isolated from AE...
ORGANISM(S): Mus musculus 
2023-01-25 | GSE215113 | GEO
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