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ProteomicsInceptor binds and directs insulin to lysosomal degradation in -cells
Blunted first-phase insulin secretion and insulin deficiency are early signs of -cell dysfunction and diabetes manifestation. Thus, insights into molecular mechanisms that regulate insulin homeostasis might provide entry sites to replenish insulin content and restore -cell function. Here, we identif...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD040758 | Pride
Cdms Inceptor 
GenomicsInceptor counteracts insulin signalling in β-cells to control glycaemia
Inceptor counteracts insulin signalling in β-cells to control glycaemia
PRJNA603905 | ENA
ProteomicsInceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility
Spermatogenesis is a crucial biological process that enables the production of functional sperm, allowing for successful reproduction. Proper germ cell differentiation and maturation require tight regulation of hormonal signals, cellular signaling pathways, and cell biological processes. The acrosom...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-28 | PXD043946 | Pride
Vesicle Localization Acrosome Differentiation Spermatogenesis Male fertility 
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD046256 | Pride
Insulin inhibitory receptor Inceptor Insulin inceptor Diet-induced obesity Glucose homeostasis 
TranscriptomicsInceptor counteracts insulin signalling in β-cells to control glycaemia
Resistance to insulin and insulin-like growth factor 1 (IGF1) in pancreatic β-cells causes overt diabetes in mice; thus, therapies that sensitize β-cells to insulin may protect patients with diabetes against β-cell failure. Here we identify an inhibitor of insulin receptor (INSR) and IGF1 receptor (...
ORGANISM(S): Mus musculus 
2021-01-27 | GSE144519 | GEO
UnknownInceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility.
Not available
S-EPMC10483240 | biostudies-literature
GenomicsInceptor binds to and directs insulin towards lysosomal degradation in beta-cells
Inceptor binds to and directs insulin towards lysosomal degradation in beta-cells
PRJNA939837 | ENA
UnknownInceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration.
Not available
S-EPMC10074927 | biostudies-literature
UnknownInceptor binds to and directs insulin towards lysosomal degradation in β cells.
Not available
S-EPMC11659164 | biostudies-literature
UnknownGlobal, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.
Not available
S-EPMC10963260 | biostudies-literature
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